Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors.
about
Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparumErythrocyte lysis and Xenopus laevis oocyte rupture by recombinant Plasmodium falciparum hemolysin IIIHydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial EvaluationEnzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium bergheiA high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assayEvaluation of aminohydantoins as a novel class of antimalarial agents.Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design.Altered plasmodial surface anion channel activity and in vitro resistance to permeating antimalarial compounds.In vitro and in vivo antimalarial activity of amphiphilic naphthothiazolium salts with amine-bearing side chains.Structural studies of vacuolar plasmepsinsIdentification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug developmentThe antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains.Threonine peptidases as drug targets against malaria.Trafficked Proteins-Druggable in Plasmodium falciparum?Successful application of virtual screening and molecular dynamics simulations against antimalarial molecular targets.Antimalarial activity of 4-metoxychalcones: docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate.Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation.The prokaryotic ClpQ protease plays a key role in growth and development of mitochondria in Plasmodium falciparum.Flap Dynamics in Aspartic Proteases: A Computational Perspective.Deciphering the targets of retroviral protease inhibitors in Plasmodium bergheiEvidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter
P2860
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P2860
Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Role of Plasmodium falciparum ...... aspartic protease inhibitors.
@en
Role of Plasmodium falciparum ...... aspartic protease inhibitors.
@nl
type
label
Role of Plasmodium falciparum ...... aspartic protease inhibitors.
@en
Role of Plasmodium falciparum ...... aspartic protease inhibitors.
@nl
prefLabel
Role of Plasmodium falciparum ...... aspartic protease inhibitors.
@en
Role of Plasmodium falciparum ...... aspartic protease inhibitors.
@nl
P2860
P356
P1476
Role of Plasmodium falciparum ...... aspartic protease inhibitors.
@en
P2093
John B Dame
Pedro A Moura
P2860
P304
P356
10.1128/AAC.00882-09
P407
P577
2009-09-14T00:00:00Z