A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
about
YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3.PML Surfs into HIPPO Tumor Suppressor Pathway.RUNX family: Regulation and diversification of roles through interacting proteins.How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.The mammalian Hippo pathway: regulation and function of YAP1 and TAZ.A balancing act: orchestrating amino-truncated and full-length p73 variants as decisive factors in cancer progression.The RUNX family: developmental regulators in cancer.Tyrosine phosphorylation of WW proteins.The E3 ligase Itch in immune regulation and beyond.The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.The E3 ubiquitin ligase Itch regulates tumor suppressor protein RASSF5/NORE1 stability in an acetylation-dependent manner.Effect of Mst1 overexpression on the growth of human hepatocellular carcinoma HepG2 cells and the sensitivity to cisplatin in vitro.The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl.Hippo signaling: to die or not to die.The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth.MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer.RUNX1 binds YAP1The complex of RUNX1 and YAP1 binds the ITCH gene promoterITCH gene expression is stimulated by RUNX1 and YAP1YAP1 binds TP73ITCH polyubiquitinates TP73RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer.
P2860
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P2860
A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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name
A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
@en
A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
@nl
type
label
A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
@en
A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
@nl
prefLabel
A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
@en
A regulatory circuit controlling Itch-mediated p73 degradation by Runx.
@nl
P2860
P356
P1476
A regulatory circuit controlling Itch-mediated p73 degradation by Runx
@en
P2093
Nina Reuven
Yosef Shaul
P2860
P304
27462-27468
P356
10.1074/JBC.M803941200
P407
P50
P577
2008-08-12T00:00:00Z