Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation - Wikidata - awgldk - TriplyDB

Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation

Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation

http://www.wikidata.org/entity/Q39953240

about

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice Hepcidin and Host Defense against Infectious Diseases.Iron metabolism and the innate immune response to infection Ironing out Ferroportin Siderocalin inhibits the intracellular replication of Mycobacterium tuberculosis in macrophages Pathophysiological consequences and benefits of HFE mutations: 20 years of research.Taming the elephant: Salmonella biology, pathogenesis, and prevention.Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate.Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-alpha and macrophage migration inhibitory factor concentrations in African children.The role of iron in the immune response to bacterial infection Severe iron deficiency blunts the response of the iron regulatory gene Hamp and pro-inflammatory cytokines to lipopolysaccharide.Hfe deficiency impairs pulmonary neutrophil recruitment in response to inflammation.Cross-talk between iron homeostasis and intestinal inflammation.Silencing airway epithelial cell-derived hepcidin exacerbates sepsis induced acute lung injury.Iron, inflammation, and early death in adults with sickle cell disease.Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy.Iron homeostasis and the inflammatory response The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease Salmonella adhesion, invasion and cellular immune responses are differentially affected by iron concentrations in a combined in vitro gut fermentation-cell model.Iron and immunity: immunological consequences of iron deficiency and overload.Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis.Nramp1 and Other Transporters Involved in Metal Withholding during Infection.Commensal Bacteria-Induced Inflammasome Activation in Mouse and Human Macrophages Is Dependent on Potassium Efflux but Does Not Require Phagocytosis or Bacterial Viability.Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens.Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation Hereditary Hemochromatosis Predisposes Mice to Yersinia pseudotuberculosis Infection Even in the Absence of the Type III Secretion System Iron and intestinal immunity.The ferric enterobactin transporter Fep is required for persistent Salmonella enterica serovar typhimurium infection.Hepcidin regulation of iron transport Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner.Iron overload and toxicity: the hidden risk of multiple blood transfusions.Ironing out the wrinkles in host defense: interactions between iron homeostasis and innate immunity.Blood-induced joint disease: the pathophysiology of hemophilic arthropathy.Iron and the immune system.HFE gene variants affect iron in the brain.Molecular biology of atherosclerosis.

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P2860

Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation

http://www.wikidata.org/entity/Q39953240

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Attenuated inflammatory respon ...... acrophage cytokine translation

@en

Attenuated inflammatory respon ...... crophage cytokine translation.

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type

label

Attenuated inflammatory respon ...... acrophage cytokine translation

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Attenuated inflammatory respon ...... crophage cytokine translation.

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Attenuated inflammatory respon ...... acrophage cytokine translation

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Attenuated inflammatory respon ...... crophage cytokine translation.

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Attenuated inflammatory respon ...... acrophage cytokine translation

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Bobby J Cherayil

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Erin E Johnson

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Hai Ning Shi

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Lijian Wang

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Marianne Wessling-Resnick

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W Allan Walker

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P2860

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism

The C282Y mutation causing hereditary hemochromatosis does not produce a null allele

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin

Regulation of iron metabolism by hepcidin

HFE gene knockout produces mouse model of hereditary hemochromatosis

Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

Identification of small molecule inhibitors that distinguish between non-transferrin bound iron uptake and transferrin-mediated iron transport.

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2723-2731

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2561261

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