Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

Item
http://www.wikidata.org/entity/Q39958607
Phase-I dose finding and pharmacokinetic study of the novel hydrophilic camptothecin ST-1968 (namitecan) in patients with solid tumors.Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents.The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives.An overview of quinoline as a privileged scaffold in cancer drug discovery.Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation.Preclinical evaluation of the novel 7-substituted camptothecin Namitecan (ST1968) in paediatric tumour models.Reconstruction of Alar Nasal Cartilage Defects Using a Tissue Engineering Technique Based on a Combined Use of Autologous Chondrocyte Micrografts and Platelet-rich Plasma: Preliminary Clinical and Instrumental Evaluation.PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy.Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?Liver protein profiles in insulin receptor-knockout mice reveal novel molecules involved in the diabetes pathophysiology.
P2860

Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.

Item
http://www.wikidata.org/entity/Q39958607
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
@en
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
@nl
type
label
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
@en
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
@nl
prefLabel
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
@en
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968.
@en
P2093
P304
P31
P356
10.1158/1535-7163.MCT-08-0266
P433
P478
P50
P577
P698