Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.
about
The emerging role of FTY720 (Fingolimod) in cancer treatmentLeptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemmaSphingosine kinase-1 is central to androgen-regulated prostate cancer growth and survival.Combination of RAD001 (everolimus) and docetaxel reduces prostate and breast cancer cell VEGF production and tumour vascularisation independently of sphingosine-kinase-1.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Sphingosine kinase 1 in cancer.Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cellsInterdiction of sphingolipid metabolism to improve standard cancer therapies.The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cellsSphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degenerationLeptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathwayDefining a role for sphingosine kinase 1 in p53-dependent tumors.Targeting sphingosine kinase-1 to inhibit melanoma.Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer.Neutralizing S1P inhibits intratumoral hypoxia, induces vascular remodelling and sensitizes to chemotherapy in prostate cancer.Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner.Evolving standards in the treatment of docetaxel-refractory castration-resistant prostate cancerEssential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer.Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signalingAcid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapySphingosine kinase 1 promotes malignant progression in colon cancer and independently predicts survival of patients with colon cancer by competing risk approach in South asian population.Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapyTherapeutic potential of targeting sphingosine kinase 1 in prostate cancer.Sphingosine 1-phosphate signalling in cancer.Oncogenic properties of sphingosine kinases in haematological malignancies.Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-κB pathway in hepatocellular carcinoma.Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells.Everolimus (RAD001) sensitizes prostate cancer cells to docetaxel by down-regulation of HIF-1α and sphingosine kinase 1.The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways.Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detectionLysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models.Roles of ceramide synthase and ceramide clearence genes in nilotinib-induced cell death in chronic myeloid leukemia cells.Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells.Core shell lipid-polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment of metastatic prostate cancer.
P2860
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P2860
Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Chemosensitizing effects of sp ...... cancer cell and animal models.
@en
Chemosensitizing effects of sp ...... cancer cell and animal models.
@nl
type
label
Chemosensitizing effects of sp ...... cancer cell and animal models.
@en
Chemosensitizing effects of sp ...... cancer cell and animal models.
@nl
prefLabel
Chemosensitizing effects of sp ...... cancer cell and animal models.
@en
Chemosensitizing effects of sp ...... cancer cell and animal models.
@nl
P2093
P50
P1476
Chemosensitizing effects of sp ...... cancer cell and animal models
@en
P2093
Bernard Malavaud
Jonathan Waxman
Maria Naymark
Muriel Golzio
Nicolas Doumerc
Takafumi Kohama
P304
P356
10.1158/1535-7163.MCT-07-2322
P577
2008-07-01T00:00:00Z