Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
about
Pharmacology and physiology of gastrointestinal enteroendocrine cellsRegulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.Novel Zn2+ Modulated GPR39 Receptor Agonists Do Not Drive Acute Insulin Secretion in Rodents.New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2.Zinc and myocardial ischemia/reperfusion injury.Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions.Discovery and Characterization of Novel GPR39 Agonists Allosterically Modulated by Zinc.Fatty acid and mineral receptors as drug targets for gastrointestinal disorders.Zn(2+) at a cellular crossroads.GPR39-1b, the 5-transmembrane isoform of GPR39 interacts with neurotensin receptor NTSR1 and modifies its function.The ZnR/GPR39 interacts with the CaSR to enhance signaling in prostate and salivary epithelia.Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39).Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists.Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease.Zinc is an agonist of GPR39Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-κB.
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P2860
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
@en
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
@nl
type
label
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
@en
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
@nl
prefLabel
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
@en
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
@nl
P2860
P1433
P1476
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.
@en
P2093
Laura Storjohann
P2860
P304
P356
10.1016/J.FEBSLET.2008.06.030
P407
P577
2008-06-25T00:00:00Z