Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
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Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SETPhosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's diseaseProtein phosphatases and Alzheimer's diseaseReduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's diseaseEpigenetics of Aging and Alzheimer's Disease: Implications for Pharmacogenomics and Drug ResponseDexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro.Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signalingmTOR-dependent signalling in Alzheimer's diseaseMemantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive ImpairmentGenetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia.Dysregulation of tau phosphorylation in mouse brain during excitotoxic damageCytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegenerationRetinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam.The role of tau in Alzheimer's disease and related disorders.Alzheimer disease therapeutics: focus on the disease and not just plaques and tanglesEnvironmental factors in the development and progression of late-onset Alzheimer's disease.Cholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer's DiseaseGSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner.Visualizing the microtubule-associated protein tau in the nucleus.Epigenetics in Alzheimer's Disease: Perspective of DNA Methylation.Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line.Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury.Neuroprotective effects of donepezil against Aβ42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3β and nAChRs activity.A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer's Disease
P2860
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P2860
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
@en
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
@nl
type
label
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
@en
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
@nl
prefLabel
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
@en
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
@nl
P2093
P1476
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.
@en
P2093
Cecilia Bjorkdahl
Heikki Tanila
Jan-Ake Gustafsson
Jin-Jing Pei
Xin-Wen Zhou
P304
P356
10.1016/J.NBD.2008.05.013
P577
2008-07-23T00:00:00Z