Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. - Wikidata - awgldk - TriplyDB

Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia.

Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia.

http://www.wikidata.org/entity/Q39978369

about

Malignant hyperthermia: a review Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3.Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity.Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum.Bilayer measurement of endoplasmic reticulum Ca2+ channels.Enhanced ER Ca2+ store filling by overexpression of SERCA2b promotes IP3-evoked puffs.Store overload-induced Ca2+ release as a triggering mechanism for CPVT and MH episodes caused by mutations in RYR and CASQ genes.IP(3) receptors: toward understanding their activation.Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output.Ryanodine receptors: structure and function.Functional interaction between calsequestrin and ryanodine receptor in the heart.Dysregulation of calcium homeostasis in muscular dystrophies.Coupling of excitation to Ca2+ release is modulated by dysferlin.[Malignant hyperthermia syndrome in the intensive care unit : Differential diagnosis and acute measures].Sevoflurane modulation of Ca2+ regulation in skeletal muscle sarcoplasmic reticulum vesicles from young and mature rabbits.Fiber hypertrophy and increased oxidative capacity can occur simultaneously in pig glycolytic skeletal muscle.Voltage modulates halothane-triggered Ca2+ release in malignant hyperthermia-susceptible muscle.Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2.Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease.

P2860

Q26799652-A6E75B3A-B244-4693-866F-87A917352494 Q28118185-9AA4A916-EE10-4ACE-ABD9-3E5D97714E21 Q30008804-E72982F5-35B0-4B9C-9DFF-17A1A195A285 Q34028253-E26D7744-21F3-4971-8201-70C57C180C58 Q34439584-57AFBCCA-DADA-4824-B1B9-59BEAA7C0FC7 Q35049794-E941DBD1-825A-4EAE-BF1D-76374D44F510 Q35112622-3617F1A0-E082-40E7-8FAC-AAC663C3D57D Q37536606-4435E6C6-B84F-4DD5-BF7F-8523064E76FD Q37803478-711A5F8A-9A18-4063-B6EC-EF2D4928F5FD Q38004648-CA2282A7-D6CF-4CAC-9B6F-F33E1AB8F096 Q38028455-2FB5F3A1-6F8A-4C4B-8F0B-0686D515ACF0 Q38056435-EA16D2AF-E309-4EA9-B16F-D4D6EA0D24E8 Q38257886-3F0A8679-FFC9-4286-839C-C5D5E89593CB Q38751812-FC42C843-F2F0-447F-A7A2-611651FF5EBC Q40102418-AD6F6590-ACBE-41D0-8F29-357FCF9294F3 Q43253388-11A284A5-D272-4753-AFCC-25E9C7F1C0A6 Q44756162-4A724A14-12F4-45EA-9917-D6011A892093 Q47220248-B55E1D9E-7E44-4743-B680-8EF7BEAA2EA9 Q48256492-AE444C62-245A-4C01-9555-8D9D0231899B Q49577286-E380E210-32C1-4ED7-BD1E-FB6410D6C1DB

P2860

Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia.

http://www.wikidata.org/entity/Q39978369

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Reduced threshold for luminal ...... orcine malignant hyperthermia.

@en

Reduced threshold for luminal ...... orcine malignant hyperthermia.

@nl

type

label

Reduced threshold for luminal ...... orcine malignant hyperthermia.

@en

Reduced threshold for luminal ...... orcine malignant hyperthermia.

@nl

prefLabel

Reduced threshold for luminal ...... orcine malignant hyperthermia.

@en

Reduced threshold for luminal ...... orcine malignant hyperthermia.

@nl

P1433

Q39978369-FA982990-F9BE-4158-9540-182D05D11ACC

P1476

Q39978369-8F0ED366-5634-4CAF-8A48-E74BFA18E057

P2093

Q39978369-0D0D3C55-8595-4326-89FA-FA3C05A8058D

Q39978369-13559424-C56A-4023-B239-DBA8C175C728

Q39978369-2E0B975A-5B42-49A0-AA92-4C8165D108CB

Q39978369-313D992E-AE1A-47B7-95B9-BF8D43BA2E4C

Q39978369-52C9459E-BE4C-4CFC-986C-1BA6B89B1D1F

Q39978369-A9E9E12D-0088-4791-B7D8-EC91AC543DEC

Q39978369-DD595448-FC1A-4B58-8B47-0CB6F6533EEC

Q39978369-E21EB510-8FF1-4894-8CA6-E5E11FEAB926

Q39978369-E4FCB89D-8F28-490D-9FB4-80CBEBE83B50

P2860

Q39978369-05DB36D2-4683-4915-B775-4E387DBBD839

Q39978369-0AD6603A-0565-4F8E-B5C4-CA06BA89E8DA

Q39978369-18DEFD23-5A3A-484F-97BD-D763591B7191

Q39978369-1DD7F7FB-3392-4837-8AD1-37AF282BE08B

Q39978369-237A56CB-AA0F-42FC-8F74-483567BD08EE

Q39978369-23FBB4E5-15EF-4758-8374-F4BB99EF5F35

Q39978369-2678B32A-41DB-47DA-9C00-A251976FC48F

Q39978369-301F353D-A60E-4E34-BFBC-6E45F5919531

Q39978369-3112CF8C-195E-45AB-9B08-2AA2240F2E32

Q39978369-369DF422-0A04-4F1C-A142-388391C2B361

P304

Q39978369-9256BF53-DF2C-4CF2-97C8-CC6569B1D46C

P31

Q39978369-C81E6530-B869-4740-84DC-BE7220DEF739

P356

Q39978369-CFE8C114-8063-4F88-BE44-15766D19BEB4

P407

Q39978369-B706D8C5-5263-460E-AAE8-DE8D2B38ED48

P433

Q39978369-F329D9EA-065C-49F0-92D6-E8EA235B2713

P478

Q39978369-E2DB06F4-BA9D-43AD-94C9-565734AF5215

P577

Q39978369-B530D5A2-9254-4C8F-9DD0-6D8075F7D378

P698

Q39978369-031C7106-69C3-4EC2-A45A-73710E8A7B1D

P932

Q39978369-77AA5C63-3322-4D58-B7FB-4682F42E66C2

P356

P1433

Journal of Biological Chemistry

P1476

Reduced threshold for luminal ...... orcine malignant hyperthermia.

@en

P2093

Bradley Fruen

http://www.w3.org/2001/XMLSchema#string

Dawei Jiang

http://www.w3.org/2001/XMLSchema#string

Huihui Kong

http://www.w3.org/2001/XMLSchema#string

Jianmin Xiao

http://www.w3.org/2001/XMLSchema#string

Lin Zhang

http://www.w3.org/2001/XMLSchema#string

Peter P Jones

http://www.w3.org/2001/XMLSchema#string

Ruiwu Wang

http://www.w3.org/2001/XMLSchema#string

S R Wayne Chen

http://www.w3.org/2001/XMLSchema#string

Wenqian Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Divergent effects of the malignant hyperthermia-susceptible Arg(615)-->Cys mutation on the Ca(2+) and Mg(2+) dependence of the RyR1.

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

The point mutation Arg615-->Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia

Cardiac excitation-contraction coupling

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)

Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death

Direct in vivo monitoring of sarcoplasmic reticulum Ca2+ and cytosolic cAMP dynamics in mouse skeletal muscle.

Abnormality in calcium release from skeletal sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia

Ryanodine receptor mutations in malignant hyperthermia and central core disease.

Reduced inhibitory effect of Mg2+ on ryanodine receptor-Ca2+ release channels in malignant hyperthermia.

P304

20813-20820

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M801944200

http://www.w3.org/2001/XMLSchema#string

P407

P433

30

http://www.w3.org/2001/XMLSchema#string

P478

283

http://www.w3.org/2001/XMLSchema#string

P577

2008-05-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

18505726

http://www.w3.org/2001/XMLSchema#string

P932

2475718

http://www.w3.org/2001/XMLSchema#string