Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).
about
The role of oxidative stress in Parkinson's diseaseEvaluation of Models of Parkinson's DiseaseGlucocerebrosidase 1 deficient Danio rerio mirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell deathAromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functionsTissue- and cell-specific mitochondrial defect in Parkin-deficient miceEffects of 6-hydroxydopamine exposure on motor activity and biochemical expression in zebrafish (Danio rerio) larvaeParkin is protective against proteotoxic stress in a transgenic zebrafish modelMutant Parkin impairs mitochondrial function and morphology in human fibroblastsZebrafish models of TauopathyBioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization.Hypokinesia and reduced dopamine levels in zebrafish lacking β- and γ1-synucleins.Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.High-throughput screening and small animal models, where are we?Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.Parkinson's disease: insights from pathways.Mitochondrial function in Antarctic nototheniids with ND6 translocationThe zebrafish homologue of the human DYT1 dystonia gene is widely expressed in CNS neurons but non-essential for early motor system developmentDopaminergic neuronal loss and dopamine-dependent locomotor defects in Fbxo7-deficient zebrafish.Modeling neurodegeneration in zebrafishHuman disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease.From omics to drug metabolism and high content screen of natural product in zebrafish: a new model for discovery of neuroactive compound.α3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish.How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs.Zebrafish as a model to understand autophagy and its role in neurological disease.Dopaminergic and noradrenergic circuit development in zebrafish.Zebrafish kidney development: basic science to translational research.Mitophagy and neurodegeneration: the zebrafish model system.Determining synthesis rates of individual proteins in zebrafish (Danio rerio) with low levels of a stable isotope labelled amino acid.Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues.Studying Autophagy in Zebrafish.Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure.Unraveling protein misfolding diseases using model systemsUpregulated Parkin expression protects mitochondrial homeostasis in DJ-1 konckdown cells and cells overexpressing the DJ-1 L166P mutation.The Pael-R gene does not mediate the changes in rotenone-induced Parkinson's disease model cells.Studies on sensitivity of zebrafish as a model organism for Parkinson's disease: Comparison with rat model.Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase.
P2860
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P2860
Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Complex I deficiency and dopam ...... cient zebrafish (Danio rerio).
@en
Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish
@nl
type
label
Complex I deficiency and dopam ...... cient zebrafish (Danio rerio).
@en
Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish
@nl
prefLabel
Complex I deficiency and dopam ...... cient zebrafish (Danio rerio).
@en
Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish
@nl
P2093
P2860
P50
P356
P1433
P1476
Complex I deficiency and dopam ...... cient zebrafish (Danio rerio).
@en
P2093
Katrin Volkmann
Laura Flinn
Reinhard W Köster
P2860
P304
P356
10.1093/BRAIN/AWP108
P407
P577
2009-05-12T00:00:00Z