Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism.
about
A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer.Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL.Anti-apoptotic BFL-1 is the major effector in activation-induced human mast cell survivalTargeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' modeReduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells.Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cellsLipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.Guiding TRAIL to cancer cells through Kv10.1 potassium channel overcomes resistance to doxorubicin.Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1.Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosisPolymeric delivery of siRNA for dual silencing of Mcl-1 and P-glycoprotein and apoptosis induction in drug-resistant breast cancer cells.Roscovitine sensitizes leukemia and lymphoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells.The effect of the combined action of roscovitine and Paclitaxel on the apoptotic and cell cycle regulatory mechanisms in colon and anaplastic thyroid cancer cells.PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cellsR-roscovitine sensitizes anaplastic thyroid carcinoma cells to TRAIL-induced apoptosis via regulation of IKK/NF-kappaB pathway.Silencing of the polyamine catabolic key enzyme SSAT prevents CDK inhibitor-induced apoptosis in Caco-2 colon cancer cells.Seliciclib in malignancies.Conditioning neoadjuvant therapies for improved immunotherapy of cancer.Reduction of phosphorylated Thr-161 Cdk1 level participates in roscovitine-induced Fas ligand-mediated apoptosis in rat eggs cultured in vitro.
P2860
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P2860
Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年学术文章
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2008年學術文章
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2008年學術文章
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name
Roscovitine sensitizes breast ...... rough a pleiotropic mechanism.
@en
Roscovitine sensitizes breast ...... rough a pleiotropic mechanism.
@nl
type
label
Roscovitine sensitizes breast ...... rough a pleiotropic mechanism.
@en
Roscovitine sensitizes breast ...... rough a pleiotropic mechanism.
@nl
prefLabel
Roscovitine sensitizes breast ...... rough a pleiotropic mechanism.
@en
Roscovitine sensitizes breast ...... rough a pleiotropic mechanism.
@nl
P2093
P2860
P50
P356
P1433
P1476
Roscovitine sensitizes breast ...... rough a pleiotropic mechanism.
@en
P2093
Ana I López-Pérez
Gustavo Ortiz-Ferrón
Ruggero De Maria
P2860
P2888
P304
P356
10.1038/CR.2008.54
P577
2008-06-01T00:00:00Z