The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines.
about
A phase I safety study of enzastaurin plus bortezomib in the treatment of relapsed or refractory multiple myeloma.Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cellsSubcellular proteomic approach for identifying the signaling effectors of protein kinase C-β₂ under high glucose conditions in human umbilical vein endothelial cellsTargeting PKC: a novel role for beta-catenin in ER stress and apoptotic signalingKinase inhibitors as potential agents in the treatment of multiple myeloma.AKT as a therapeutic target in multiple myeloma.AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.Multifunctional roles of PKCδ: Opportunities for targeted therapy in human diseasePI3KCA plays a major role in multiple myeloma and its inhibition with BYL719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance.Molecular events underlying interleukin-6 independence in a subclone of the CMA-03 multiple myeloma cell line.Combination of low doses of enzastaurin and lenalidomide has synergistic activity in B-non-Hodgkin lymphoma cell lines.A novel bisindolymaleimide derivative (WK234) inhibits proliferation and induces apoptosis through the protein kinase Cβ pathway, in chronic myelogenous leukemia K562 cells.Apoptotic induction in B-cell acute lymphoblastic leukemia cell lines treated with a protein kinase Cβ inhibitor.Effects of enzastaurin, alone or in combination, on signaling pathway controlling growth and survival of B-cell lymphoma cell lines.Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes.A novel selective small-molecule PI3K inhibitor is effective against human multiple myeloma in vitro and in vivo.Protein kinase C isoforms in the normal pancreas and in pancreatic disease.Novel phosphatidylinositol 3-kinase inhibitor BKM120 enhances the sensitivity of multiple myeloma to bortezomib and overcomes resistance.
P2860
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P2860
The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
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2008年学术文章
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2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
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2008年學術文章
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2008年學術文章
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name
The oral protein-kinase C beta ...... n multiple myeloma cell lines.
@en
The oral protein-kinase C beta ...... n multiple myeloma cell lines.
@nl
type
label
The oral protein-kinase C beta ...... n multiple myeloma cell lines.
@en
The oral protein-kinase C beta ...... n multiple myeloma cell lines.
@nl
prefLabel
The oral protein-kinase C beta ...... n multiple myeloma cell lines.
@en
The oral protein-kinase C beta ...... n multiple myeloma cell lines.
@nl
P2093
P2860
P50
P1433
P1476
The oral protein-kinase C beta ...... in multiple myeloma cell lines
@en
P2093
Donata Verdelli
Giorgio Lambertenghi Deliliers
Luigia Lombardi
Maria Cosenza
Monica Civallero
Pierfrancesco Tassone
P2860
P304
P356
10.1080/10428190802078289
P50
P577
2008-07-01T00:00:00Z