Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
about
Function, regulation and pathological roles of the Gab/DOS docking proteinsTyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4Shp2 confers cisplatin resistance in small cell lung cancer via an AKT-mediated increase in CA916798.New insights into signalling networks regulating breast cancer stem cells.Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancerSHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.Targeting protein tyrosine phosphatases for anticancer drug discovery.Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.Three interrelated themes in current breast cancer research: gene addiction, phenotypic plasticity, and cancer stem cells.Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway.Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.Functions of Shp2 in cancer.Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signalingSHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer.The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migrationMolecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α.ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their sensitivity to EGFR inhibition.Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells.SHP2 overexpression enhances the invasion and metastasis of ovarian cancer in vitro and in vivo.Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer.Oncogenic Shp2 disturbs microtubule regulation to cause HDAC6-dependent ERK hyperactivation.Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival.Covalent inhibition of protein tyrosine phosphatases.The tyrosine phosphatase SHP2 associates with CUB domain-containing protein-1 (CDCP1), regulating its expression at the cell surface in a phosphorylation-dependent mannerOncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1.[Expression and its clinical significance of SHP2 in non-small cell lung cancer].The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma.Vanadium Compounds as PTP Inhibitors.Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition.Expression and clinical significance of SHP2 in gastric cancer.Thyroid Cancer Detection by Ultrasound Molecular Imaging with SHP2-Targeted Perfluorocarbon Nanoparticles.The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma.
P2860
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P2860
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
@en
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
@nl
type
label
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
@en
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
@nl
prefLabel
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
@en
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
@nl
P2860
P356
P1476
Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells.
@en
P2093
P2860
P2888
P304
P356
10.1038/CDD.2008.54
P577
2008-04-18T00:00:00Z
P5875
P6179
1025204115