Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome.
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Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome BrainThe biology of pediatric acute megakaryoblastic leukemiaMyeloid leukemia in Down syndromeStructure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibitionMS-1020 is a novel small molecule that selectively inhibits JAK3 activity.NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3Hsa-mir-125b-2 is highly expressed in childhood ETV6/RUNX1 (TEL/AML1) leukemias and confers survival advantage to growth inhibitory signals independent of p53Array-based genomic resequencing of human leukemia.Down syndrome--recent progress and future prospects.Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia.Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia.Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.Normal and malignant megakaryopoiesis.Constitutional aneuploidy and cancer predisposition.Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndromeJAK3: a two-faced player in hematological disordersPerspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinasesJAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia.Identification of mutant alleles of JAK3 in pediatric patients with acute lymphoblastic leukemia.HiJAKing the epigenome in leukemia and lymphoma.Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3 mutations in normal subjects.Specific calpain inhibition protects kidney against inflammaging.Advances in the understanding and management of T-cell prolymphocytic leukemia.Precision Medicine in Children and Young Adults with Hematologic Malignancies and Blood Disorders: The Columbia University Experience.Gene alterations involving the CRLF2-JAK pathway and recurrent gene deletions in Down syndrome-associated acute lymphoblastic leukemia in Japan.Newly described activating JAK3 mutations in T-cell acute lymphoblastic leukemia.
P2860
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P2860
Functional analysis of JAK3 mutations in transient myeloproliferative disorder and acute megakaryoblastic leukaemia accompanying Down syndrome.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Functional analysis of JAK3 mu ...... ia accompanying Down syndrome.
@en
Functional analysis of JAK3 mu ...... ia accompanying Down syndrome.
@nl
type
label
Functional analysis of JAK3 mu ...... ia accompanying Down syndrome.
@en
Functional analysis of JAK3 mu ...... ia accompanying Down syndrome.
@nl
prefLabel
Functional analysis of JAK3 mu ...... ia accompanying Down syndrome.
@en
Functional analysis of JAK3 mu ...... ia accompanying Down syndrome.
@nl
P2093
P2860
P1476
Functional analysis of JAK3 mu ...... ia accompanying Down syndrome.
@en
P2093
Etsuro Ito
Hirokazu Kanegane
Hiroyuki Mano
Hitoshi Kiyoi
Kiminori Terui
Masahiro Migita
Masayoshi Miura
Mikiya Endo
Rika Kanezaki
P2860
P304
P356
10.1111/J.1365-2141.2008.07081.X
P407
P577
2008-04-07T00:00:00Z