Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
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The PCSK9 decadeMechanisms and genetic determinants regulating sterol absorption, circulating LDL levels, and sterol elimination: implications for classification and disease riskA PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivoA proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia.The genetic basis of familial hypercholesterolemia: inheritance, linkage, and mutations.PCSK9: a convertase that coordinates LDL catabolism.Genetics of familial hypercholesterolemia.PCSK9 function and physiologyStudies of the autoinhibitory segment comprising residues 31-60 of the prodomain of PCSK9: Possible implications for the mechanism underlying gain-of-function mutations.c-IAP1 binds and processes PCSK9 protein: linking the c-IAP1 in a TNF-α pathway to PCSK9-mediated LDLR degradation pathway.PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.Loss- and gain-of-function PCSK9 variants: cleavage specificity, dominant negative effects, and low density lipoprotein receptor (LDLR) degradationPCSK9 function and physiology.PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum.Characterisation of de novo mutations in the C-terminal domain of proprotein convertase subtilisin/kexin type 9.
P2860
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P2860
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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2008年學術文章
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name
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
@en
type
label
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
@en
prefLabel
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
@en
P2093
P2860
P1476
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
@en
P2093
Ayesha Sitlani
Carl P Sparrow
Doug Wisniewski
Joseph C Santoro
Richard T Cummings
Rose M Cubbon
Samuel D Wright
Shilpa Pandit
Sookhee Ha
Timothy S Fisher
P2860
P304
P356
10.1194/JLR.M800049-JLR200
P577
2008-03-19T00:00:00Z