about
Intermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk.Insight into odorant perception: the crystal structure and binding characteristics of antibody fragments directed against the musk odorant traseolideSelection, characterization and x-ray structure of anti-ampicillin single-chain Fv fragments from phage-displayed murine antibody librariesThe importance of framework residues H6, H7 and H10 in antibody heavy chains: experimental evidence for a new structural subclassification of antibody V(H) domainsCrystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigenDevelopment of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adaptersStructural basis for eliciting a cytotoxic effect in HER2-overexpressing cancer cells via binding to the extracellular domain of HER2DARPin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein CrystallographyComputationally Designed Armadillo Repeat Proteins for Modular Peptide RecognitionAll autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptorSelection for improved protein stability by phage display.Direct in vivo screening of intrabody libraries constructed on a highly stable single-chain framework.Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach.Biophysical properties of human antibody variable domains.Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library.Reproducing the natural evolution of protein structural features with the selectively infective phage (SIP) technology. The kink in the first strand of antibody kappa domains.A mutation designed to alter crystal packing permits structural analysis of a tight-binding fluorescein-scFv complex.DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency.Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations.Stability improvement of antibodies for extracellular and intracellular applications: CDR grafting to stable frameworks and structure-based framework engineering.Affinity and folding properties both influence the selection of antibodies with the selectively infective phage (SIP) methodology.Engineering antibodies for stability and efficient folding.Receptor-targeted lentiviral vectors are exceptionally sensitive toward the biophysical properties of the displayed single-chain Fv.Efficient cell-specific uptake of binding proteins into the cytoplasm through engineered modular transport systems.CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells.The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework.Cytoplasmic domains determine signal specificity, cellular routing characteristics and influence ligand binding of epidermal growth factor and insulin receptors.A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites.Kinetic parameters of the protein tyrosine kinase activity of EGF-receptor mutants with individually altered autophosphorylation sites.A combined NMR and computational approach to investigate peptide binding to a designed Armadillo repeat protein.Rigidly connected multispecific artificial binders with adjustable geometries.Expression of a human insulin-like growth factor II cDNA in NIH-3T3 cells.Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity.Comparison of buffers and detection systems for high-pressure liquid chromatography of peptide mixtures.Metabolic effects induced by epidermal growth factor (EGF) in cells expressing EGF receptor mutants.Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase.Chemical modification of peptides by hydrazine.
P50
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P50
description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Annemarie Honegger
@ast
Annemarie Honegger
@en
Annemarie Honegger
@es
type
label
Annemarie Honegger
@ast
Annemarie Honegger
@en
Annemarie Honegger
@es
prefLabel
Annemarie Honegger
@ast
Annemarie Honegger
@en
Annemarie Honegger
@es
P106
P21
P31
P496
0000-0002-3378-3967