Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.
about
Molecular biology of lung cancerTargeting RTK Signaling Pathways in CancerTargeted therapies in development for non-small cell lung cancerAKT1E¹⁷K Is Oncogenic in Mouse Lung and Cooperates with Chemical Carcinogens in Inducing Lung CancerTargeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092Computational identification of significant missense mutations in AKT1 gene.Absence of AKT1 mutations in glioblastoma.Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.Molecular pathways and therapeutic targets in lung cancerThe PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.ALK-rearrangements and testing methods in non-small cell lung cancer: a reviewPhosphatidylinositol 4,5-bisphosphate-specific AKT1 is oncogenic.Mutation frequency in 15 common cancer genes in high-risk head and neck squamous cell carcinoma.Non-Small Cell Lung Carcinoma Biomarker Testing: The Pathologist's PerspectiveAkt1 deletion prevents lung tumorigenesis by mutant K-ras.Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain.Signaling networks associated with AKT activation in non-small cell lung cancer (NSCLC): new insights on the role of phosphatydil-inositol-3 kinase.Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas.Targeting the PI3K/Akt/mTOR pathway in hepatocellular carcinoma.Regulation of Akt signaling activation by ubiquitination.Molecularly targeted therapies in non-small-cell lung cancer annual update 2014Novel candidate key drivers in the integrative network of genes, microRNAs, methylations, and copy number variations in squamous cell lung carcinoma.Targetable "driver" mutations in non small cell lung cancer.Treatment of nonsmall cell lung cancer: overcoming the resistance to epidermal growth factor receptor inhibitors.Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.K63-linked ubiquitination in kinase activation and cancer.Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.Phosphorylated AKT1 is associated with poor prognosis in esophageal squamous cell carcinoma.Genetic changes in squamous cell lung cancer: a reviewGenetic and biochemical alterations in non-small cell lung cancer.Translating genomic information into clinical medicine: lung cancer as a paradigm.Clarifying the spectrum of driver oncogene mutations in biomarker-verified squamous carcinoma of lung: lack of EGFR/KRAS and presence of PIK3CA/AKT1 mutations.Mutant AKT1-E17K is oncogenic in lung epithelial cellsThe Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells.Personalizing therapy in advanced non-small cell lung cancerGene-expression profiles in lung adenocarcinomas related to chronic wood smoke or tobacco exposure.The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias.A novel AKT3 mutation in melanoma tumours and cell linesTargeting genomic alterations in squamous cell lung cancer.New strategies in squamous cell carcinoma of the lung: identification of tumor drivers to personalize therapy.
P2860
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P2860
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Activating E17K mutation in th ...... us cell carcinoma of the lung.
@en
type
label
Activating E17K mutation in th ...... us cell carcinoma of the lung.
@en
prefLabel
Activating E17K mutation in th ...... us cell carcinoma of the lung.
@en
P2093
P50
P356
P1433
P1476
Activating E17K mutation in th ...... us cell carcinoma of the lung.
@en
P2093
Carmela De Marco
Fernanda Fabiani
Gennaro Chiappetta
Giuseppe Pirozzi
Giuseppe Viglietto
Marianna Scrima
Natalia Malara
Nicla De Rosa
Rocco Savino
Silvia De Gisi
P304
P356
10.4161/CC.7.5.5485
P577
2007-12-26T00:00:00Z