A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.
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Ca2+-dependent modulation of voltage-gated Ca2+ channelsMultiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerizationThe individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heartGenetic disruption of voltage-gated calcium channels in psychiatric and neurological disordersCalmodulin regulation (calmodulation) of voltage-gated calcium channelsStructure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channelsTowards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium ChannelsThe calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1.2 and Cav1.3 channelsStructures of CaV2 Ca2+/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and FacilitationDeterminants in CaV1 Channels That Regulate the Ca2+ Sensitivity of Bound CalmodulinModular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticityStructural Basis for the Differential Effects of CaBP1 and Calmodulin on CaV1.2 Calcium-Dependent InactivationDistinct properties of Ca 2+ –calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channelStructural basis for the regulation of L-type voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca2+-calmodulinStructural Basis for Calmodulin as a Dynamic Calcium SensorCapping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic releaseCalmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channelsSeparate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibitionInteraction of calmodulin with Sec61α limits Ca2+ leakage from the endoplasmic reticulum.RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin miceStructure and Calcium Binding Properties of a Neuronal Calcium-Myristoyl Switch Protein, Visinin-Like Protein 3.Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytesTranscript diversification in the nervous system: a to I RNA editing in CNS function and disease developmentDevelopmental alterations in the biophysical properties of Ca(v) 1.3 Ca(2+) channels in mouse inner hair cells.Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes.Molecular endpoints of Ca2+/calmodulin- and voltage-dependent inactivation of Ca(v)1.3 channelsIntra- and interdomain effects due to mutation of calcium-binding sites in calmodulinNeuronal calcium sensor-1 (Ncs1p) is up-regulated by calcineurin to promote Ca2+ tolerance in fission yeast.Levamisole and ryanodine receptors. II: An electrophysiological study in Ascaris suum.Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.Calmodulation meta-analysis: predicting calmodulin binding via canonical motif clustering.Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activatorsTransient receptor potential (TRP) and Cch1-Yam8 channels play key roles in the regulation of cytoplasmic Ca2+ in fission yeast.Calcineurin determines toxic versus beneficial responses to α-synuclein.Multiple Ca2+-dependent mechanisms regulate L-type Ca2+ current in retinal amacrine cells.Continuously tunable Ca(2+) regulation of RNA-edited CaV1.3 channels.G protein modulation of CaV2 voltage-gated calcium channelsCaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels.Ca(V)1.2 channel N-terminal splice variants modulate functional surface expression in resistance size artery smooth muscle cellsStructural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1.
P2860
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P2860
A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
A modular switch for spatial C ...... in regulation of CaV channels.
@en
type
label
A modular switch for spatial C ...... in regulation of CaV channels.
@en
prefLabel
A modular switch for spatial C ...... in regulation of CaV channels.
@en
P2093
P2860
P356
P1433
P1476
A modular switch for spatial C ...... lin regulation of CaV channels
@en
P2093
David T Yue
Haoya Liang
Lai Hock Tay
Michael R Tadross
Wanjun Yang
P2860
P2888
P304
P356
10.1038/NATURE06529
P407
P50
P577
2008-01-30T00:00:00Z
P5875
P6179
1030041292