Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
about
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domaintBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome cBcl-G, a novel pro-apoptotic member of the Bcl-2 familyProto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosisGlioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressorGRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosisThe BH3-only protein Bad confers breast cancer taxane sensitivity through a nonapoptotic mechanismProtein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosisRationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studiesWISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinaseInduction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathwaySolution structure of a Bcl-2 homolog from Kaposi sarcoma virus.Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis.Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinaseThe proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrestPim kinase inhibitors: a survey of the patent literatureConstitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cellsA splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitrop53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARCTransforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cellsInactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activationp70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BADInsulin signaling regulates mitochondrial function in pancreatic beta-cellsRecent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family.Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels.Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains.Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins.Activation of apoptosis and its inhibition.Tissue-specific Bcl-2 protein partners in apoptosis: An ovarian paradigm.The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.Cytokine-induced tumor suppressors: a GRIM storyControlling the mitochondrial gatekeeper for effective chemotherapy.Role of the mitochondrial signaling pathway in murine coronavirus-induced oligodendrocyte apoptosis.Bcl-2 family proteins as targets for anticancer drug design.Multiple functions of BCL-2 family proteins.Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatmentCross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.Killing of sarcoma cells by proapoptotic Bcl-X(S): role of the BH3 domain and regulation by Bcl-X(L).
P2860
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P2860
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
@en
type
label
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
@en
prefLabel
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
@en
P2093
P2860
P356
P1476
Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.
@en
P2093
P2860
P304
P356
10.1128/MCB.17.12.7040
P407
P577
1997-12-01T00:00:00Z