Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
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Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traitsMetabolic insight into mechanisms of high-altitude adaptation in TibetansGene knockout of Acc2 has little effect on body weight, fat mass, or food intakeA diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial functionThe adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial functionA general introduction to the biochemistry of mitochondrial fatty acid β-oxidationMetabolomics and Type 2 Diabetes: Translating Basic Research into Clinical ApplicationRegulation of skeletal muscle mitochondrial activity by thyroid hormones: focus on the "old" triiodothyronine and the "emerging" 3,5-diiodothyronineMitochondrial fatty acid oxidation in obesityInsulin resistance protects the heart from fuel overload in dysregulated metabolic statesThe mitochondria in diabetic heart failure: from pathogenesis to therapeutic promiseInterplay between lipids and branched-chain amino acids in development of insulin resistanceImplications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesityHow exercise may amend metabolic disturbances in diabetic cardiomyopathyAcylcarnitines: reflecting or inflicting insulin resistance?MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese MiceBile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance ratePreservation of metabolic flexibility in skeletal muscle by a combined use of n-3 PUFA and rosiglitazone in dietary obese miceDietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolismAdult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestationLipidomics-Reshaping the Analysis and Perception of Type 2 DiabetesThe cell biology of fat expansionEstrogen: an emerging regulator of insulin action and mitochondrial functionA branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistanceBranched-chain amino acids in metabolic signalling and insulin resistanceCholine supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon actionIn obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidationMitochondrial health, the epigenome and healthspanTranslating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitineAnti-Diabetic Effects of Jiang Tang Xiao Ke Granule via PI3K/Akt Signalling Pathway in Type 2 Diabetes KKAy MiceLong-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondriaTranscriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traitsPlasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American womenUnmasking differential effects of rosiglitazone and pioglitazone in the combination treatment with n-3 fatty acids in mice fed a high-fat dietActivity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese miceSIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylaseIncreased metabolic rate and insulin sensitivity in male mice lacking the carcino-embryonic antigen-related cell adhesion molecule 2Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in miceBiochemical competition makes fatty-acid β-oxidation vulnerable to substrate overloadGestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle
P2860
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P2860
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Mitochondrial overload and inc ...... tal muscle insulin resistance.
@en
type
label
Mitochondrial overload and inc ...... tal muscle insulin resistance.
@en
prefLabel
Mitochondrial overload and inc ...... tal muscle insulin resistance.
@en
P2093
P50
P1433
P1476
Mitochondrial overload and inc ...... tal muscle insulin resistance.
@en
P2093
Christopher B Newgard
Dorothy Slentz
Gary D Lopaschuk
Jason R B Dyck
John R Ussher
Olga Ilkayeva
Robert C Noland
Robert Stevens
Timothy R Koves
P356
10.1016/J.CMET.2007.10.013
P577
2008-01-01T00:00:00Z