Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse.
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CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorderImage-guided drug delivery to the brain using nanotechnology.Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders.Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse.Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma.Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor.Brain-penetrating tumor necrosis factor decoy receptor in the mouse.Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differencesExpression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein.Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein.Delivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein.Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor.The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain BarrierNovel treatment strategies for brain tumors and metastases.Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion proteinComparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptorPharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in miceTargeting receptor-mediated transport for delivery of biologics across the blood-brain barrier.Biopharmaceutical drug targeting to the brain.Strategies for delivery of therapeutics into the central nervous system for treatment of lysosomal storage disorders.Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti-transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity.Novel and emerging strategies in drug delivery for overcoming the blood-brain barrier.Shuttle-mediated drug delivery to the brain.Transduction of human recombinant proteins into mitochondria as a protein therapeutic approach for mitochondrial disorders.Targeting nanoparticles across the blood-brain barrier with monoclonal antibodies.Targeted delivery of protein and gene medicines through the blood-brain barrier.Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's diseaseLysosomal enzyme replacement therapies: Historical development, clinical outcomes, and future perspectives.Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies.Targeting, endocytosis, and lysosomal delivery of active enzymes to model human neurons by ICAM-1-targeted nanocarriers.In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors.Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier.Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse.Receptor-mediated abeta amyloid antibody targeting to Alzheimer's disease mouse brainSelective plasma pharmacokinetics and brain uptake in the mouse of enzyme fusion proteins derived from species-specific receptor-targeted antibodies.CHO cell expression, long-term stability, and primate pharmacokinetics and brain uptake of an IgG-paroxonase-1 fusion protein.Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology.Drug transport across the blood-brain barrier
P2860
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P2860
Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Engineering and expression of ...... barrier delivery in the mouse.
@en
type
label
Engineering and expression of ...... barrier delivery in the mouse.
@en
prefLabel
Engineering and expression of ...... barrier delivery in the mouse.
@en
P2860
P356
P1476
Engineering and expression of ...... barrier delivery in the mouse.
@en
P2093
Yuntao Wang
P2860
P304
P356
10.1002/BIT.22135
P577
2009-03-01T00:00:00Z