Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1.
about
High-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity.Rational Combinations of Targeted Agents in AML90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.HSP-90 inhibitor ganetespib is synergistic with doxorubicin in small cell lung cancer.CHK1 overexpression in T-cell acute lymphoblastic leukemia is essential for proliferation and survival by preventing excessive replication stress.Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells.Assessment of lipid peroxidation and p53 as a biomarker of carcinogenesis among workers exposed to formaldehyde in the cosmetic industry.
P2860
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P2860
Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Hsp90-inhibitor geldanamycin a ...... through the depletion of Chk1.
@en
type
label
Hsp90-inhibitor geldanamycin a ...... through the depletion of Chk1.
@en
prefLabel
Hsp90-inhibitor geldanamycin a ...... through the depletion of Chk1.
@en
P2093
P2860
P356
P1433
P1476
Hsp90-inhibitor geldanamycin a ...... through the depletion of Chk1.
@en
P2093
K Sugimoto
K Tamayose
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210978
P407
P577
2007-12-10T00:00:00Z
P5875
P6179
1020537275