Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.

Item
http://www.wikidata.org/entity/Q40038253
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivoCyclin-dependent kinase 4-mediated phosphorylation inhibits Smad3 activity in cyclin D-overexpressing breast cancer cells.A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors.Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activationSynergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy.Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.FLIP: molecular switch between apoptosis and necroptosis.BAI, a novel cyclin-dependent kinase inhibitor induces apoptosis in A549 cells through activation of caspases and inactivation of Akt.The proteasome inhibitor MG-132 induces AIF nuclear translocation through down-regulation of ERK and Akt/mTOR pathway.Autophagy-related genes are induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid via the activation of cathepsin B in human breast cancer cells.Protective effect of Baccharis trimera extract on acute hepatic injury in a model of inflammation induced by acetaminophen.The irreversible ERBB1/2/4 inhibitor neratinib interacts with the BCL-2 inhibitor venetoclax to kill mammary cancer cells.
P2860

Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.

Item
http://www.wikidata.org/entity/Q40038253
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Extrinsic pathway- and catheps ...... hality in breast cancer cells.
@en
type
label
Extrinsic pathway- and catheps ...... hality in breast cancer cells.
@en
prefLabel
Extrinsic pathway- and catheps ...... hality in breast cancer cells.
@en
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
Extrinsic pathway- and catheps ...... hality in breast cancer cells.
@en
P2093
P304
P31
P356
10.1158/1535-7163.MCT-07-0561
P433
P478
P50
P577
P698