Munc18-1 prevents the formation of ectopic SNARE complexes in living cells.
about
Munc18/Syntaxin interaction kinetics control secretory vesicle dynamics.The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediate membrane interactions and recognition by DHHC palmitoyl transferasesThe Secret Life of Tethers: The Role of Tethering Factors in SNARE Complex RegulationDistinct initial SNARE configurations underlying the diversity of exocytosisConformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegansDynamic conformational changes in munc18 prevent syntaxin bindingThe Exocyst Subunit Sec6 Interacts with Assembled Exocytic SNARE ComplexesMunc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complexVesicle fusion probability is determined by the specific interactions of munc18SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation.A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion.t-SNARE protein conformations patterned by the lipid microenvironment.Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cellsInvolvement of Rab3A in vesicle priming during exocytosis: interaction with Munc13-1 and Munc18-1.Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complexThe functions of Munc18-1 in regulated exocytosis.Resolving the function of distinct Munc18-1/SNARE protein interaction modes in a reconstituted membrane fusion assay.Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexinMunc18-1 domain-1 controls vesicle docking and secretion by interacting with syntaxin-1 and chaperoning it to the plasma membranePhosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.Synaptic vesicle fusion.Munc18a scaffolds SNARE assembly to promote membrane fusionUNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.Palmitoylation of the synaptic vesicle fusion machinery.Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.Navigation through the Plasma Membrane Molecular Landscape Shapes Random Organelle MovementImaging large cohorts of single ion channels and their activity.The Sec1/Munc18 Protein Groove Plays a Conserved Role in Interaction with Sec9p/SNAP-25.Munc18-1 protein molecules move between membrane molecular depots distinct from vesicle docking sites.Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.Managing intracellular transport.A pivotal role for pro-335 in balancing the dual functions of Munc18-1 domain-3a in regulated exocytosis.Fluorescence Lifetime Imaging Microscopy reveals rerouting of SNARE trafficking driving dendritic cell activationPhysiological fluorescence lifetime imaging microscopy improves Förster resonance energy transfer detection in living cells.BDNF-TrkB Signaling Coupled to nPKCε and cPKCβI Modulate the Phosphorylation of the Exocytotic Protein Munc18-1 During Synaptic Activity at the Neuromuscular Junction.
P2860
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P2860
Munc18-1 prevents the formation of ectopic SNARE complexes in living cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Munc18-1 prevents the formation of ectopic SNARE complexes in living cells.
@en
type
label
Munc18-1 prevents the formation of ectopic SNARE complexes in living cells.
@en
prefLabel
Munc18-1 prevents the formation of ectopic SNARE complexes in living cells.
@en
P356
P1476
Munc18-1 prevents the formation of ectopic SNARE complexes in living cells.
@en
P2093
Claire N Medine
Luke H Chamberlain
P304
P356
10.1242/JCS.020230
P407
P577
2007-12-01T00:00:00Z