A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.
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Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expressionHsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cellsAnti-HSP90 autoantibodies in sera of infertile women identify a dominant, conserved epitope EP6 (380-389) of HSP90 beta proteinExtracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionallyTargeting Hsp90 in urothelial carcinomaContribution of chaperones to STAT pathway signaling.Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccinesExtracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: implications for the prostate tumor microenvironmentA novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasionExtracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasionMedulloblastoma exosome proteomics yield functional roles for extracellular vesiclesHectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchymeThe Unmysterious Roles of HSP90: Ovarian Pathology and Autoantibodies.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.Targeting highly expressed extracellular HSP90 in breast cancer stem cells inhibits tumor growth in vitro and in vivo.Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation.Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits.Evidence of a Cell Surface Role for Hsp90 Complex Proteins Mediating Neuroblast Migration in the Subventricular Zone.An Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like ProteinProtein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA.Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.The 4C5 cell-impermeable anti-HSP90 antibody with anti-cancer activity, is composed of a single light chain dimerCell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasionThe regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesisAssociation between HSP90 and Her2 in gastric and gastroesophageal carcinomas.Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program.Extracellular molecules involved in cancer cell invasionInteractions between Hsp90 and oncogenic viruses: implications for viral cancer therapeuticsDifferentially expressed proteins in nitric oxide-stimulated NIH/3T3 fibroblasts: implications for inhibiting cancer development.Secreted heat shock protein-90 (Hsp90) in wound healing and cancer.Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule.A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumors.Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors.Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors.Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.A chemical cross-linking method for the analysis of binding partners of heat shock protein-90 in intact cells.Secreted heat shock protein 90α (HSP90α) induces nuclear factor-κB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion.
P2860
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P2860
A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A critical role for HSP90 in c ...... extracellular domain of HER-2.
@en
type
label
A critical role for HSP90 in c ...... extracellular domain of HER-2.
@en
prefLabel
A critical role for HSP90 in c ...... extracellular domain of HER-2.
@en
P2093
P2860
P356
P1476
A critical role for HSP90 in c ...... extracellular domain of HER-2.
@en
P2093
Dimitris Stellas
Evangelia Patsavoudi
Katerina Sidera
Maria Gaitanou
Rebecca Matsas
P2860
P304
P356
10.1074/JBC.M701803200
P407
P577
2007-12-05T00:00:00Z