A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.
about
Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC-96Susceptibilities of several drug-resistant herpes simplex virus type 1 strains to alternative antiviral compoundsNovel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolatesBroad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors.Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential.Genotypic characterization of the DNA polymerase and sensitivity to antiviral compounds of foscarnet-resistant herpes simplex virus type 1 (HSV-1) derived from a foscarnet-sensitive HSV-1 strain.Directed selection of recombinant human monoclonal antibodies to herpes simplex virus glycoproteins from phage display librariesResistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and managementGenotypic characterization of UL23 thymidine kinase and UL30 DNA polymerase of clinical isolates of herpes simplex virus: natural polymorphism and mutations associated with resistance to antivirals.Amino acid changes within conserved region III of the herpes simplex virus and human cytomegalovirus DNA polymerases confer resistance to 4-oxo-dihydroquinolines, a novel class of herpesvirus antiviral agentsCloning, expression, and functional characterization of the equine herpesvirus 1 DNA polymerase and its accessory subunit.Resistance of herpesviruses to antiviral drugsA point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives.Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: evidence for specificity of interaction.Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.Rapid detection and typing of herpes simplex virus DNA in clinical specimens by the hybrid capture II signal amplification probe test.Bacteriophage T4 DNA polymerase mutations that confer sensitivity to the PPi analog phosphonoacetic acid.A point mutation within conserved region VI of herpes simplex virus type 1 DNA polymerase confers altered drug sensitivity and enhances replication fidelity.Utility of the bacteriophage RB69 polymerase gp43 as a surrogate enzyme for herpesvirus orthologs.Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice.Sequence variation within three important cytomegalovirus gene regions in isolates from four different patient populations.Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragmentsIdentification of conserved residues contributing to the activities of adenovirus DNA polymerase.Exonuclease-deficient polymerase mutant of herpes simplex virus type 1 induces altered spectra of mutations.Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids.Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents."The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.Antiherpevirus activity of Artemisia arborescens essential oil and inhibition of lateral diffusion in Vero cells.Selection and characterization of Autographa californica multiple nucleopolyhedrovirus DNA polymerase mutationsCharacterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudinAnalysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks.Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture.
P2860
Q28361992-76372A1D-327D-4F3A-A27B-8175E5AEE7F6Q28367467-2FBFA66E-1F91-4AC7-B76C-FBD3859B2F19Q28367722-D65C757D-ECE5-42D4-B0D4-3410CEB9E807Q31038987-B7B1DCCC-5522-4767-A0DE-A9B153E812EFQ31998570-5AA9C66C-2100-4EA2-A1F5-75E118859664Q33804966-F0CEEA6B-C070-4270-A66D-11D934957E9DQ34127099-580D2E29-ADA4-4C58-A8DD-B35A9CED8002Q34149904-1400C808-27F0-485F-A2DA-639B4AECF2E6Q34290117-F336E99C-973E-4959-B47B-BADBF6039994Q34468784-7B3E0CF7-593A-40A3-8422-A9B36C4CD7E8Q34716750-4BCD4B7F-2C1E-4689-A782-07707ED55B54Q35447500-EE3FFBB2-8EAC-4D17-91BE-C1474DF35B34Q35807437-91C62A3F-52D0-490D-8020-C90EC1FD418CQ35838622-43632A8C-4154-4F67-B9C0-85A01DEEB167Q35895966-FA073D1A-82CD-45A6-8D1B-C56863C9358EQ36546275-E0AB5EAF-DF18-47F5-8516-184EB8FEFA0BQ36638832-A3562E87-9402-4A0E-B4F2-F211B4B05712Q36944779-C37C46C3-F22D-4F27-B709-4BE263F08287Q38072636-EF342965-CCF0-46A5-9738-C9680450726DQ38595362-B00E318B-A212-4A55-8EE5-C14BC5908496Q39555862-9E15EA9A-4ACA-4D8F-B436-C66E666EDB47Q39582502-84A24CD6-CC2D-4172-B12B-B974E9C64CD5Q39593691-220C7DCC-5E84-4015-BB25-3DA9E458CD68Q39733616-6D0FB6C3-A1EA-4360-B097-16F66A710EBFQ39776436-D4B617C7-28A0-44F6-B0D3-CA83ED887887Q40062049-8C4F15D8-9733-48AD-8C2A-60FA0A698184Q40720231-92449C27-3595-4667-BF1D-92A5CDCAB01DQ40810723-69FD5D35-D7F1-4770-B9BE-8B5D57412890Q41649331-7FDC4723-BF19-4BB5-B4C1-90AF40D31768Q41891671-FAF0C6B2-6E5D-48FD-BEDB-536BBBF52FD2Q43085703-F4A53036-9819-480F-9A04-3B6E2904853CQ55285515-97CEE150-F4A0-4A83-A851-DB1B2186C56F
P2860
A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
A point mutation within a dist ...... gene confers drug resistance.
@en
type
label
A point mutation within a dist ...... gene confers drug resistance.
@en
prefLabel
A point mutation within a dist ...... gene confers drug resistance.
@en
P2093
P2860
P1433
P1476
A point mutation within a dist ...... gene confers drug resistance.
@en
P2093
P2860
P304
P407
P577
1992-03-01T00:00:00Z