Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.
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LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cellsQuantitative FRET imaging to visualize the invasiveness of live breast cancer cellsPhthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells.The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs.Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells.Placental membrane-type metalloproteinases (MT-MMPs): Key players in pregnancy.Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cellsMutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasiaBiochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cellsProteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancyEndothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B.A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP.MMP-14 in skeletal muscle repair.Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells.Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study.
P2860
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P2860
Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Proteolysis of the membrane ty ...... tic processing and activation.
@en
type
label
Proteolysis of the membrane ty ...... tic processing and activation.
@en
prefLabel
Proteolysis of the membrane ty ...... tic processing and activation.
@en
P2093
P2860
P356
P1476
Proteolysis of the membrane ty ...... ytic processing and activation
@en
P2093
Alexander E Aleshin
Alexei V Chekanov
Boris I Ratnikov
Ilian Radichev
Jeffrey W Smith
Katarzyna Gawlik
Khatereh Motamedchaboki
Sergey A Shiryaev
Vladislav S Golubkov
P2860
P304
36283-36291
P356
10.1074/JBC.M706290200
P407
P577
2007-10-15T00:00:00Z