Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
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PLEKHG2 promotes heterotrimeric G protein βγ-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.Structural Mechanisms and Drug Discovery Prospects of Rho GTPasesModulation of actin dynamics by Rac1 to target cognitive functionApproaches of targeting Rho GTPases in cancer drug discoveryActivated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated ProteinsSmall-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activityApproach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchangeAstrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomessiRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus InfectionShank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanismApoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation.Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion.Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells.HIF-1α activation results in actin cytoskeleton reorganization and modulation of Rac-1 signaling in endothelial cellsDiscovery of MINC1, a GTPase-activating protein small molecule inhibitor, targeting MgcRacGAP.Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion.Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification.Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assayIdentification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay.Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancerControl of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinaseRegulation of Adherens Junctions in Trabecular Meshwork Cells by Rac GTPase and their influence on Intraocular Pressure.Androgen-induced cell migration: role of androgen receptor/filamin A associationAn integrated imaging approach to the study of oxidative stress generation by mitochondrial dysfunction in living cells.A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibitionG protein signaling in the parasite Entamoeba histolyticaInduction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.A novel small-molecule screening strategy identifies mitoxantrone as a RhoGTPase inhibitor.Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans.Attacking the supply wagons to starve cancer cells to death.Targeting Rho-GTPases in immune cell migration and inflammation.Death pathways triggered by activated Ras in cancer cellsPharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus.Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells.Tannerella forsythia invasion in oral epithelial cells requires phosphoinositide 3-kinase activation and clathrin-mediated endocytosis.EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells.
P2860
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P2860
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Specificity and mechanism of a ...... r of Rac family small GTPases.
@en
type
label
Specificity and mechanism of a ...... r of Rac family small GTPases.
@en
prefLabel
Specificity and mechanism of a ...... r of Rac family small GTPases.
@en
P2093
P2860
P356
P1476
Specificity and mechanism of a ...... or of Rac family small GTPases
@en
P2093
Adam Shutes
Cercina Onesto
Channing J Der
Fabien Schweighoffer
Virginie Picard
P2860
P304
35666-35678
P356
10.1074/JBC.M703571200
P407
P577
2007-10-11T00:00:00Z