Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70. - Wikidata - awgldk - TriplyDB

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

http://www.wikidata.org/entity/Q40073570

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The basal transcription machinery as a target for cancer therapy Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: A mini review Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma.Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells The Protective Effects of Isoliquiritigenin and Glycyrrhetinic Acid against Triptolide-Induced Oxidative Stress in HepG2 Cells Involve Nrf2 Activation Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.Personalized chemotherapy profiling using cancer cell lines from selectable mice Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B.Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells MUC1c regulates cell survival in pancreatic cancer by preventing lysosomal permeabilization.Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts.Celastrol, an oral heat shock activator, ameliorates multiple animal disease models of cell death.Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway.Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma.Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1.βIII-tubulin: a novel mediator of chemoresistance and metastases in pancreatic cancer Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma.Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer.High-throughput screening system for inhibitors of human Heat Shock Factor 2.Inhibition of epithelial ovarian cancer by Minnelide, a water-soluble pro-drug.Heat shock factors: integrators of cell stress, development and lifespan.Molecular targeted approaches for treatment of pancreatic cancer.Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer Wild-type p53 reactivation by small-molecule Minnelide™ in human papillomavirus (HPV)-positive head and neck squamous cell carcinoma.Minnelide Overcomes Oxaliplatin Resistance by Downregulating the DNA Repair Pathway in Pancreatic Cancer.

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P2860

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

http://www.wikidata.org/entity/Q40073570

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

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type

label

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

@en

prefLabel

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

@en

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0008-5472.CAN-07-1077

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Cancer Research

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Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

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Ashok K Saluja

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Daniel Borja-Cacho

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Joshua A McCarroll

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Phoebe A Phillips

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Rajinder K Dawra

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Selwyn M Vickers

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Vikas Dudeja

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William E Grizzle

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9407-9416

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19

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17909050

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