TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication. - Wikidata - awgldk - TriplyDB

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

http://www.wikidata.org/entity/Q40075069

about

Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport.Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans Identification of GBF1 as a Cellular Factor Required for Hepatitis C Virus RNA Replication Endocytic Rab proteins are required for hepatitis C virus replication complex formation Catalytic mechanism of a mammalian Rab{middle dot}RabGAP complex in atomic detail Skywalker-TBC1D24 has a lipid-binding pocket mutated in epilepsy and required for synaptic function Membrane dynamics associated with viral infection ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling Spatiotemporal inhibition of innate immunity signaling by the Tbc1d23 RAB-GAP.Hepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes Phosphatidylinositol 4,5-bisphosphate is an HCV NS5A ligand and mediates replication of the viral genome Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway.Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence.TBC proteins: GAPs for mammalian small GTPase Rab?Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice Treating hepatitis C infection by targeting the host.Intracellular expression of Tat alters mitochondrial functions in T cells: a potential mechanism to understand mitochondrial damage during HIV-1 replication Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation.Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly Review series: Rab GTPases and membrane identity: causal or inconsequential?Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders.Structural mechanisms for regulation of membrane traffic by rab GTPases A small molecule inhibits HCV replication and alters NS4B's subcellular distribution.Hepatitis C Virus-Induced Rab32 Aggregation and Its Implications for Virion Assembly.Viral infection: Moving through complex and dynamic cell-membrane structures.Roles of phosphoinositides and phosphoinositides kinases in hepatitis C virus RNA replication.Rab proteins as regulators of lipid droplet formation and lipolysis.RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions.Potential roles for cellular cofactors in hepatitis C virus replication complex formation.Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway.Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor.TBC1D20 mediates autophagy as a key regulator of autophagosome maturation.

P2860

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P2860

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

http://www.wikidata.org/entity/Q40075069

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

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type

label

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

@en

prefLabel

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

@en

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P1433

Journal of Biological Chemistry

P1476

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

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P2093

David G Lambright

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Ella H Sklan

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Jeffrey S Glenn

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Ramon L Serrano

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Shirit Einav

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Suzanne R Pfeffer

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P2860

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome

Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein

Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication

AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication

Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments

P304

36354-36361

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10.1074/JBC.M705221200

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50

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P478

282

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2007-09-27T00:00:00Z

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17901050

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P921

Hepatitis C virus