Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.
about
Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem CellsAML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemiaIntensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.Effects of the NUP98-DDX10 oncogene on primary human CD34+ cells: role of a conserved helicase motifTranscriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain.CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemiaSparse expression bases in cancer reveal tumor drivers.Transcriptome Profiling of Pediatric Core Binding Factor AML.Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancerPRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potentialDepletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.Combined gene expression and DNA occupancy profiling identifies potential therapeutic targets of t(8;21) AML.Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic stem cells and induces progression to myelodysplastic syndromeRUNX1T1: a novel predictor of liver metastasis in primary pancreatic endocrine neoplasmsγ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-cateninNew insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Chromosomal aberrations and fusion genes in myeloid malignancies.The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia.Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter.Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafishTLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia.Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D.Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells.RNA sequencing reveals upregulation of RUNX1-RUNX1T1 gene signatures in clear cell renal cell carcinomaDevelopmental-stage-dependent transcriptional response to leukaemic oncogene expression.RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1.OGG1 is a novel prognostic indicator in acute myeloid leukaemia.CD200 expression in plasma cells of nonmyeloma immunoproliferative disorders: clinicopathologic features and comparison with plasma cell myeloma.Domain retention in transcription factor fusion genes and its biological and clinical implications: a pan-cancer study.A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5.CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia.Therapeutic potential of apigenin, a plant flavonoid, for imatinib-sensitive and resistant chronic myeloid leukemia cells.The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation
P2860
Q27302025-41CD3853-C857-4ECE-8D54-41BFF06EB57DQ28751687-9F0BCA4F-8AC8-4B52-8E0C-94AE6D2766C9Q33629475-CDF35740-6B97-4F21-8539-B2BEF3F36C4EQ33753763-9D5F1C4D-2F9E-47D9-8B24-495B7145AEACQ33846983-CB70A66A-8474-480E-A299-91776B206F44Q34304022-2CAB2A77-7640-487E-8467-73382FA0F435Q34977414-C0857ED7-B49C-416B-99A6-02194B023690Q35088941-EB0AFAF3-20B3-41FA-A610-887710CC4B44Q35784721-B843B777-0549-4191-A416-50CCB87E31ECQ35985483-9C4D2D02-8359-4363-B74F-607A28B884CCQ36010294-A043FB1F-BA51-4B34-A73A-509B44CEBAF9Q36166902-5FBE92EF-3DBD-44A1-B80B-DDD54F61A093Q36177937-101C6B00-E6AF-4031-B98D-881C1DBFAF25Q36395604-A052B195-61AA-46A5-8013-18D1829AB210Q36518549-727C35E1-A4E4-4DBF-80F3-A18A10FD34E6Q36732802-A35B9087-6628-4482-8F73-FD18098EB8A9Q37679748-350A5170-875D-4AB7-A8B8-F2FA02B59903Q38044772-C027FB25-AC12-45EF-B366-6006AE3833C5Q38068040-FE0B718C-C801-4499-A147-17C3491E5BB0Q38345022-CC70035C-0CEE-482B-90AF-B314776F1A25Q38940260-787CAC4F-378C-4524-AA8B-A84C35454BB9Q38977867-CB527127-5763-45F0-8247-A5CB89160A85Q39445622-3FA6CF12-7487-475A-8DC1-FC6DB1D857EEQ41177054-0499DCAB-9C20-43E1-B529-74F6D050E004Q41781737-EB5263CB-8445-4643-8D93-5DA8E8D0FB5FQ41977356-019E6265-8D55-4341-B657-400F6CCF1F63Q42290452-6D8E4812-4A97-402F-B410-1F87DBA7A3CFQ42361297-FE0AA1C3-096A-413C-A63F-EBBA522F9F41Q42602670-5B5A5B50-0A97-497B-A6BB-E45B9BCA1DC7Q43207769-CA3BE11B-B7AB-4A61-8502-35B2BADE8D44Q43214271-EA673907-B184-46BD-AD67-3E55CACEB3FDQ46826314-DE614585-C64F-440C-B882-6805FB3B2755Q47164118-F51604C0-D822-48C1-BF4F-5B82E961A28FQ48721287-00200206-BD12-402B-A74E-E30280CC5919Q52848045-72E051D8-7818-433E-814C-652EBCF837A8Q54325366-ACD0DA09-60DD-4B2F-908F-57927AF5009AQ54364714-5231E7AF-CD72-4238-8D20-7986F62B6CC9Q57293716-ACBAD6A7-F10E-4AB6-A811-40BF6B89BF76
P2860
Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemia.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Transcriptional dysregulation ...... nd in acute myeloid leukaemia.
@en
type
label
Transcriptional dysregulation ...... nd in acute myeloid leukaemia.
@en
prefLabel
Transcriptional dysregulation ...... nd in acute myeloid leukaemia.
@en
P2093
P2860
P356
P1433
P1476
Transcriptional dysregulation ...... nd in acute myeloid leukaemia.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.LEU.2404961
P50
P577
2007-09-27T00:00:00Z
P5875
P6179
1013150783