Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease.
about
Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathwayMyocilin is a modulator of Wnt signalingA molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein responseOlfactomedin proteins: central players in development and diseaseCystatin a, a potential common link for mutant myocilin causative glaucomaHypo- and hypermorphic FOXC1 mutations in dominant glaucoma: transactivation and phenotypic variabilityBiophysical characterization of the olfactomedin domain of myocilin, an extracellular matrix protein implicated in inherited forms of glaucoma.Characterization of monoclonal antibodies against the glaucoma-associated protein myocilin.Functional role of proteolytic processing of recombinant myocilin in self-aggregationOlfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology.Establishment of inducible wild type and mutant myocilin-GFP-expressing RGC5 cell linesBicarbonate-dependent secretion and proteolytic processing of recombinant myocilinInteraction of recombinant myocilin with the matricellular protein SPARC: functional implicationsStructural basis for misfolding in myocilin-associated glaucoma.Cross-talk between ciliary epithelium and trabecular meshwork cells in-vitro: a new insight into glaucomaIncreased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis.Comprehensive analysis of myocilin variants in east Indian POAG patients.Technical Brief: a novel strategy for enrichment of trabecular meshwork protease proteome.Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin.CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability.Dual localization of wild-type myocilin in the endoplasmic reticulum and extracellular compartment likely occurs due to its incomplete secretion.The role of proteolytic cellular systems in trabecular meshwork homeostasisA Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture.Functional characterization of eight rare missense CYP1B1 variants involved in congenital glaucoma and their association with null genotypes.Anticipation, anti-glaucoma drug treatment response and phenotype of a Chinese family with glaucoma caused by the Pro370Leu myocilin mutation
P2860
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P2860
Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Characterization of the intrac ...... myocilin-processing protease.
@en
type
label
Characterization of the intrac ...... myocilin-processing protease.
@en
prefLabel
Characterization of the intrac ...... myocilin-processing protease.
@en
P2093
P2860
P356
P1476
Characterization of the intrac ...... a myocilin-processing protease
@en
P2093
Francisco Martínez-Redondo
Francisco Sánchez-Sánchez
Miguel Coca-Prados
P2860
P304
27810-27824
P356
10.1074/JBC.M609608200
P407
P577
2007-07-24T00:00:00Z