Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.

Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.

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http://www.wikidata.org/entity/Q40108262

Q40108262

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Oncolytic viruses as therapeutic cancer vaccines A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies HDAC inhibitors and immunotherapy; a double edged sword?Impact of the MICA-129Met/Val Dimorphism on NKG2D-Mediated Biological Functions and Disease Risks NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma The narrow-spectrum HDAC inhibitor entinostat enhances NKG2D expression without NK cell toxicity, leading to enhanced recognition of cancer cells Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway.Immunotherapy for pediatric cancer.Genetics, genomics, and evolutionary biology of NKG2D ligands.Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies.Expression of MICA, MICB and NKG2D in human leukemic myelomonocytic and cervical cancer cells.Interpreting clinical assays for histone deacetylase inhibitors.γδ T cells and epigenetic drugs: A useful merger in cancer immunotherapy?Regulation of immune responses by histone deacetylase inhibitors The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation.Valproic acid upregulates NKG2D ligand expression through an ERK-dependent mechanism and potentially enhances NK cell-mediated lysis of myeloma.Association of MICA-TM and MICB C1_2_A microsatellite polymorphisms with tumor progression in patients with colorectal cancer.Natural killer cells and malignant haemopathies: a model for the interaction of cancer with innate immunity.How to improve the immunogenicity of chemotherapy and radiotherapy.Mechanisms of tumor and viral immune escape from natural killer cell-mediated surveillance.Modulation of antigen-presenting cells by HDAC inhibitors: implications in autoimmunity and cancer.Targeting NKG2D in tumor surveillance.Combination strategies to enhance antitumor ADCC.Shaping of NK cell responses by the tumor microenvironment Novel immune modulators used in hematology: impact on NK cells Immunotherapeutic approaches to treat multiple myeloma Molecular Bases for the Regulation of NKG2D Ligands in Cancer.γδ T cells as a potential tool in colon cancer immunotherapy.Role of NKG2D in cytokine-induced killer cells against lung cancer.Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia.Molecular mechanisms of HLA class I-mediated immune evasion of human tumors and their role in resistance to immunotherapies.The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma.Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA.Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands.Role of NKG2D in cytokine-induced killer cells against multiple myeloma cells.Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.Ex vivo differentiation of natural killer cells from human umbilical cord blood CD34+ progenitor cells.Induction of NKG2D ligands and increased sensitivity of tumor cells to NK cell-mediated cytotoxicity by hematoporphyrin-based photodynamic therapy.Studies of the H60a locus in C57BL/6 and 129/Sv mouse strains identify the H60a 3'UTR as a regulator of H60a expression.

P2860

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P2860

Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.

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http://www.wikidata.org/entity/Q40108262

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2007 nî lūn-bûn

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name

Regulation of the expression o ...... ity of NKG2D-expressing cells.

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Regulation of the expression o ...... ity of NKG2D-expressing cells.

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Regulation of the expression o ...... ity of NKG2D-expressing cells.

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P1476

Regulation of the expression o ...... ity of NKG2D-expressing cells.

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Asaka M

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P2860

Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB

Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA

Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor

The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression

Effects of histone acetylation and DNA methylation on p21( WAF1) regulation

Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells

Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells

HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

P2888

sj.leu.2404862

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10.1038/SJ.LEU.2404862

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cytotoxicity

leukemia

Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.

about

P2860

P2860

Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.

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