The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation.
about
Janus kinases in immune cell signalingSelectivity and therapeutic inhibition of kinases: to be or not to be?Jak2 inhibitors: rationale and role as therapeutic agents in hematologic malignancies.Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis.SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.Tofacitinab in renal transplantation.JAK2 inhibitors do not affect stem cells present in the spleens of patients with myelofibrosis.Understanding the biology of CRLF2-overexpressing acute lymphoblastic leukemiaGenetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibitionTSLP signaling network revealed by SILAC-based phosphoproteomicsJAK Kinases in Health and Disease: An UpdateUpdate on JAK2 Inhibitors in Myeloproliferative NeoplasmComprehensive review of JAK inhibitors in myeloproliferative neoplasms.A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells.Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction.Mechanistic medicine: novel strategies for clinical trials.Janus kinase inhibitors for the treatment of myeloproliferative neoplasias and beyond.Improving outcomes for high-risk ALL: translating new discoveries into clinical care.Genetic Interactions of STAT3 and Anticancer Drug Development.Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6.Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor.Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor.INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell supportDisruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor.IL10 receptor is a novel therapeutic target in DLBCLs.Imetelstat, a telomerase inhibitor, is capable of depleting myelofibrosis stem and progenitor cells
P2860
Q24322021-AA4CAAAD-8480-4F04-8CED-76DCF3C5CF8FQ24656006-D0D433EE-7E93-4AFE-B7C9-89103525BE3CQ33586552-2269594B-E1E7-44B1-BD5E-1D1FC543819FQ34084020-8F90D683-FC4D-44C9-A7E0-B9B0BA633DC3Q34194226-90BB69E2-004E-4B40-A314-D155B9A27214Q34357184-8D981CB1-A06F-46B1-9AB2-63E405505096Q34471806-D02C079E-0452-4294-AD6A-EA8BBE94A29AQ35500533-62ACBEA2-E4C2-450F-A8DF-475C5668DF44Q35760845-CEBD28DF-9E2C-4D06-9519-49F9FC3DDA64Q36208936-4E074B6E-71A9-4420-8677-A9F45B7B2F90Q36285745-5AFCD3FB-4594-47CA-8E88-4388DDABDFBAQ36612569-958045E7-7821-4ECC-8297-47D4141C558DQ36776428-6C1B24C7-FBBA-4E67-A535-D6AFC00C3CA5Q37058118-F8958C84-86B3-42DB-9A24-3887582C4247Q37541469-7FF31380-9962-4BDB-97C1-515F6D538ACEQ37739484-C05D828D-1F6D-4550-BB70-4F7C4513A04FQ37833893-C6919F95-FF49-4C32-BF67-60191BFC2F8EQ37849259-B74A4C2C-104E-48B1-9EC0-73C03D771856Q38198930-B6F33A76-37CE-471E-896C-AD8DD2624A5FQ38979718-C6D2C138-8E3E-4BBE-9AD6-65FCF59AF228Q39554914-DDC43E26-7948-4880-A61D-0E82833E5B53Q39717742-3681DE2A-746B-472D-8D26-A929E3D4181FQ39752237-26850767-0801-44CE-B8F1-E1BA39CAC092Q47117432-D94630F1-0F2A-4B9E-8CEF-BCB9A41BA836Q48219985-76A45438-1F3E-405C-ADC0-4DB4DEE20B56Q58705137-603BE83D-0C9A-4EAB-AB89-5393088A307C
P2860
The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The JAK kinase inhibitor CP-69 ...... rrying the JAK2V617F mutation.
@en
type
label
The JAK kinase inhibitor CP-69 ...... rrying the JAK2V617F mutation.
@en
prefLabel
The JAK kinase inhibitor CP-69 ...... rrying the JAK2V617F mutation.
@en
P2093
P2860
P50
P1433
P1476
The JAK kinase inhibitor CP-69 ...... rrying the JAK2V617F mutation.
@en
P2093
Alfonso Quintás-Cardama
Amos Gaikwad
Josef Prchal
Roberto H Nussenzveig
Taghi Manshouri
P2860
P304
P356
10.1111/J.1349-7006.2008.00817.X
P577
2008-06-01T00:00:00Z