Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia.
about
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemiaCHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cellsTherapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammationAction mechanisms of histone deacetylase inhibitors in the treatment of hematological malignanciesCell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old playerFrom Drosophila to humans: reflections on the roles of the prolyl isomerases and chaperones, cyclophilins, in cell function and diseaseHow animal models of leukaemias have already benefited patientsThe calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells.vSDC: a method to improve early recognition in virtual screening when limited experimental resources are availableThe role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimusSecreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathwayAcute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.NFAT proteins: emerging roles in cancer progression.Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell.Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells.Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1.Specific targeting of caspase-9/PP2A interaction as potential new anti-cancer therapyTCR-dependent transformation of mature memory phenotype T cells in mice.Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.Calcineurin homologous protein: a multifunctional Ca2+-binding protein family.Loss of endogenous Nfatc1 reduces the rate of DMBA/TPA-induced skin tumorigenesis.Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signalingNFAT2 Isoforms Differentially Regulate Gene Expression, Cell Death, and Transformation through Alternative N-Terminal Domains.NFAT as cancer target: mission possible?Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors.Activation of NFAT signaling establishes a tumorigenic microenvironment through cell autonomous and non-cell autonomous mechanisms.NFAT1 transcription factor regulates cell cycle progression and cyclin E expression in B lymphocytesHistone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma.Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5Cyclosporine A for chemotherapy-resistant subcutaneous panniculitis-like T cell lymphoma with hemophagocytic syndrome.NFAT gene family in inflammation and cancer.Potential therapeutic targets and small molecular drugs for pediatric B-precursor acute lymphoblastic leukemia treatment based on microarray dataMicroenvironmental cues for T-cell acute lymphoblastic leukemia development.Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer.Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.Cholinergic Machinery as Relevant Target in Acute Lymphoblastic T LeukemiaSuccessful treatment of chemotherapy-refractory angioimmunoblastic T cell lymphoma with cyclosporin A.Calcineurin complex isolated from T-cell acute lymphoblastic leukemia (T-ALL) cells identifies new signaling pathways including mTOR/AKT/S6K whose inhibition synergize with calcineurin inhibition to promote T-ALL cell death.
P2860
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P2860
Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Targeting calcineurin activati ...... acute lymphoblastic leukemia.
@en
type
label
Targeting calcineurin activati ...... acute lymphoblastic leukemia.
@en
prefLabel
Targeting calcineurin activati ...... acute lymphoblastic leukemia.
@en
P2093
P356
P1433
P1476
Targeting calcineurin activati ...... acute lymphoblastic leukemia.
@en
P2093
Anne Janin
Caroline Berthier
Didier Decaudin
Hind Medyouf
Hélène Alcalde
Jacques Ghysdael
Marie Claude Guillemin
Nuno R dos Santos
P2888
P304
P356
10.1038/NM1588
P407
P577
2007-05-21T00:00:00Z