Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase.
about
Novel binding partners and differentially regulated phosphorylation sites clarify Eps8 as a multi-functional adaptorThe interplay between Eps8 and IRSp53 contributes to Src-mediated transformation.Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cellsQuantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry.P66shc and its downstream Eps8 and Rac1 proteins are upregulated in esophageal cancers.p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase.c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8).EPS8 inhibition increases cisplatin sensitivity in lung cancer cells.Molecular parameters of head and neck cancer metastasis.Identification of human leukemia antigen A*0201-restricted epitopes derived from epidermal growth factor pathway substrate number 8Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages.Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms.Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation.Epidermal growth factor receptor kinase substrate 8 promotes the metastasis of cervical cancer via the epithelial-mesenchymal transitionCytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human diseaseProgress in researches about focal adhesion kinase in gastrointestinal tract.Identification of HLA‑A*1101‑restricted cytotoxic T lymphocyte epitopes derived from epidermal growth factor pathway substrate number 8.Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Novel oncoprotein EPS8: a new target for anticancer therapy.Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation.Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.Expression of Eps8 correlates with poor survival in oral squamous cell carcinoma.Differential roles of EPS8 in carcinogenesis: loss of protein expression in a subset of colorectal carcinoma and adenoma.The effect of focal adhesion kinase gene silencing on 5-fluorouracil chemosensitivity involves an Akt/NF-kappaB signaling pathway in colorectal carcinomas.Role for EPS8 in squamous carcinogenesis.Chaperone-mediated autophagy substrate proteins in cancer.Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium.Role of ERK/mTOR signaling in TGFbeta-modulated focal adhesion kinase mRNA stability and protein synthesis in cultured rat IEC-6 intestinal epithelial cells.EPS8 regulates proliferation, apoptosis and chemosensitivity in BCR-ABL positive cells via the BCR-ABL/PI3K/AKT/mTOR pathway.PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia.
P2860
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P2860
Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Eps8 facilitates cellular grow ...... vity of focal adhesion kinase.
@en
type
label
Eps8 facilitates cellular grow ...... vity of focal adhesion kinase.
@en
prefLabel
Eps8 facilitates cellular grow ...... vity of focal adhesion kinase.
@en
P2093
P356
P1476
Eps8 facilitates cellular grow ...... vity of focal adhesion kinase.
@en
P2093
Ching-Chung Huang
Jenq-Chang Lee
Ming-Chei Maa
Nan-Haw Chow
Shan-Tair Wang
Tzeng-Horng Leu
Yen-Jen Chen
Yuch-Ching Lee
Yun-Ju Chen
P304
19399-19409
P356
10.1074/JBC.M610280200
P407
P577
2007-05-12T00:00:00Z