The design of artificial retroviral restriction factors.
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Independent evolution of an antiviral TRIMCyp in rhesus macaquesCyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site.Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid ProteinThe tripartite motif coiled-coil is an elongated antiparallel hairpin dimer.Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid latticeRhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfacesRhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral coreApparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αsBirth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomesMechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.Hexagonal assembly of a restricting TRIM5alpha proteinOrdered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1Novel approaches to inhibiting HIV-1 replication.Simplification, Innateness, and the Absorption of Meaning from Context: How Novelty Arises from Gradual Network EvolutionThe specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain.Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.Antiretroviral restriction factors in mice.Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.Evolution of the retroviral restriction gene Fv1: inhibition of non-MLV retroviruses.Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins.The effect of exon 7 deletion during the evolution of TRIMCyp fusion proteins on viral restriction, cytoplasmic body formation and multimerization.Murine leukemia viruses: objects and organisms.Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5alpha B-box 2 domain.Comparative requirements for the restriction of retrovirus infection by TRIM5alpha and TRIMCypOligomerization Requirements for MX2-Mediated Suppression of HIV-1 InfectionChance favors a prepared genome.Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species.Restriction of foamy viruses by primate Trim5alphaThe TRIM5alpha B-box 2 domain promotes cooperative binding to the retroviral capsid by mediating higher-order self-associationBiochemical and biophysical characterization of a chimeric TRIM21-TRIM5alpha proteinBiochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses.Target cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A.The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating.Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection.Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5αIFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.An active TRIM5 protein in rabbits indicates a common antiviral ancestor for mammalian TRIM5 proteins.TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition.A general model for retroviral capsid pattern recognition by TRIM5 proteins.
P2860
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P2860
The design of artificial retroviral restriction factors.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The design of artificial retroviral restriction factors.
@en
type
label
The design of artificial retroviral restriction factors.
@en
prefLabel
The design of artificial retroviral restriction factors.
@en
P2093
P1433
P1476
The design of artificial retroviral restriction factors.
@en
P2093
Gulnahar B Mortuza
Ian A Taylor
Melvyn W Yap
P304
P356
10.1016/J.VIROL.2007.04.005
P407
P577
2007-05-09T00:00:00Z