Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia.
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Molecular and therapeutic potential and toxicity of valproic acidHistone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agentsVorinostat induces apoptosis and differentiation in myeloid malignancies: genetic and molecular mechanisms10058-F4, a c-Myc inhibitor, markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells.The histone deacetylase inhibitor valproic acid sensitizes diffuse large B-cell lymphoma cell lines to CHOP-induced cell death.Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.Analyzing gene expression profile in K562 cells exposed to sodium valproate using microarray combined with the connectivity map databaseGene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells.Using an exon microarray to identify a global profile of gene expression and alternative splicing in K562 cells exposed to sodium valproate.Mesenchymal stem cells induce granulocytic differentiation of acute promyelocytic leukemic cells via IL-6 and MEK/ERK pathways.Molecular dissection of valproic acid effects in acute myeloid leukemia identifies predictive networks.The Histone Deacetylase Inhibitor Valproic Acid Sensitizes Gemcitabine-Induced Cytotoxicity in Gemcitabine-Resistant Pancreatic Cancer Cells Possibly Through Inhibition of the DNA Repair Protein Gamma-H2AX.Knockdown of CD44 enhances chemosensitivity of acute myeloid leukemia cells to ADM and Ara-C.Valproic acid inhibits proliferation of EB virus-infected natural killer cells.Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.Synergistic effect of bortezomib and valproic acid treatment on the proliferation and apoptosis of acute myeloid leukemia and myelodysplastic syndrome cells.Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells.Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation.In vitro anticancer drug test: A new method emerges from the model of glioma stem cells.Valproic acid may exerts its cytotoxic effect through rassf1a expression induction in acute myeloid leukemia.Synergistic induction of PI-PLCβ1 signaling by azacitidine and valproic acid in high-risk myelodysplastic syndromes
P2860
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P2860
Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Downregulation of c-Myc is cri ...... ion of acute myeloid leukemia.
@en
type
label
Downregulation of c-Myc is cri ...... ion of acute myeloid leukemia.
@en
prefLabel
Downregulation of c-Myc is cri ...... ion of acute myeloid leukemia.
@en
P2093
P1433
P1476
Downregulation of c-Myc is cri ...... ion of acute myeloid leukemia.
@en
P2093
H Eugene Liu
Hsiupen Lin
Jyh-Ming Chow
Ming-Jer Huang
Shufan Lin
Yun-Chih Cheng
P304
P356
10.1016/J.LEUKRES.2007.03.012
P577
2007-04-18T00:00:00Z