Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
about
Solution-phase parallel synthesis of a multi-substituted benzo[b]thiophene library.Diverse methyl sulfone-containing benzo[b]thiophene library via iodocyclization and palladium-catalyzed coupling.Tubulin inhibitors: pharmacophore modeling, virtual screening and molecular docking.Synthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells.Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.Synthesis and biological evaluation of benzo[b]furans as inhibitors of tubulin polymerization and inducers of apoptosis.Tubulin inhibitor identification by bioactive conformation alignment pharmacophore-guided virtual screening.An overview of tubulin inhibitors that interact with the colchicine binding siteSynthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-N,N-dimethylamino benzo[b]furan derivatives as inhibitors of tubulin polymerization.Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-6-substituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives as antimitotic agents and inhibitors of tubulin polymerizationSynthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity.Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.Concise synthesis and biological evaluation of 2-Aroyl-5-amino benzo[b]thiophene derivatives as a novel class of potent antimitotic agents.Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents.Synthesis and structure elucidation of some novel thiophene and benzothiophene derivatives as cytotoxic agents.Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes.Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones.2-amino-3,4,5-trimethoxybenzophenones as potent tubulin polymerization inhibitors.An efficient synthesis of N-substituted 3-nitrothiophen-2-amines.Binding conformations and QSAR of CA-4 analogs as tubulin inhibitors.Chemoselective Ullmann coupling at room temperature: a facile access to 2-aminobenzo[b]thiophenes.Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site.Original research paper. Synthesis and antitumor activity of some novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives.Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.
P2860
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P2860
Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Synthesis and biological evalu ...... ors of tubulin polymerization.
@en
type
label
Synthesis and biological evalu ...... ors of tubulin polymerization.
@en
prefLabel
Synthesis and biological evalu ...... ors of tubulin polymerization.
@en
P2093
P50
P356
P1476
Synthesis and biological evalu ...... tors of tubulin polymerization
@en
P2093
Antonella Di Cristina
Delia Preti
Ernest Hamel
Francesca Fruttarolo
Jan Balzarini
John A Hadfield
Maria Dora Carrion
Maria Giovanna Pavani
Mojgan Aghazadeh Tabrizi
Pier Giovanni Baraldi
P304
P356
10.1021/JM070050F
P407
P577
2007-04-10T00:00:00Z