Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.

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Synthesis of α-branched acyclic nucleoside phosphonates as potential inhibitors of bacterial adenylate cyclases.Patent Highlights June-July 2017.

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P2860

Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.

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2017 nî lūn-bûn

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Acyclic Nucleoside Phosphonate ...... ne Phosphoribosyltransferases.

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Acyclic Nucleoside Phosphonate ...... ne Phosphoribosyltransferases.

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Acyclic Nucleoside Phosphonate ...... ne Phosphoribosyltransferases.

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Acyclic Nucleoside Phosphonate ...... ine Phosphoribosyltransferases

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P2093

Dianne T Keough

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Lenka Poštová-Slavětínská

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Luke W Guddat

http://www.w3.org/2001/XMLSchema#string

Martin Dračínský

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Martin Maxmilian Kaiser

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P2860

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The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age

The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor

Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents

First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity

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scholarly article

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10.1002/CMDC.201700293

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Zlatko Janeba

Ondřej Baszczyňski

Dana Hocková

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2017-07-11T00:00:00Z

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28628279

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Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.

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P2860

P2860

Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine and a Five-Membered Heterocycle as Selective Inhibitors of Plasmodial 6-Oxopurine Phosphoribosyltransferases.

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P2860

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P31

P356

P433

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P698