Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model. - Wikidata - awgldk - TriplyDB

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model.

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model.

http://www.wikidata.org/entity/Q40156550

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Psoriasis pathophysiology: current concepts of pathogenesis Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases Putting together the psoriasis puzzle: an update on developing targeted therapies Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk Immunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab Comparison of the effects of vitamin D products in a psoriasis plaque test and a murine psoriasis xenograft model.IL-15: a central regulator of celiac disease immunopathology.NK cells and multiple myeloma-associated endothelial cells: molecular interactions and influence of IL-27 Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin.Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22.Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities.Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.Interleukin 15 primes natural killer cells to kill via NKG2D and cPLA2 and this pathway is active in psoriatic arthritis.Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis.Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways miR-15b is Downregulated in Myasthenia Gravis Patients and Directly Regulates the Expression of Interleukin-15 (IL-15) in Experimental Myasthenia Gravis Mice Th17 cells in human disease.IL-15 receptor α signaling constrains the development of IL-17-producing γδ T cells.Mechanisms of action of mycophenolate mofetil.Active immunization with human interleukin-15 induces neutralizing antibodies in non-human primates.Human antibodies from transgenic animals.Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice Keratinocyte apoptosis in epidermal development and disease.Possible drug targets for celiac disease.Thiazolidinediones: potential as therapeutics for psoriasis and perhaps other hyperproliferative skin disease.Modeling the pharmacokinetic-pharmacodynamic relationship of the monoclonal anti-macaque-IL-15 antibody Hu714MuXHu in cynomolgus monkeys.The role of dendritic cells in the immunopathogenesis of psoriasis.Psoriasis: evolution of pathogenic concepts and new therapies through phases of translational research.Interleukin-20 as a target in psoriasis treatment.Psoriatic arthritis: genetic susceptibility and pharmacogenetics.Epidermal IL-15Rα acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.Signalling, inflammation and arthritis: Crossed signals: the role of interleukin-15 and -18 in autoimmunity.Th17 cells: a new therapeutic target in inflammatory dermatoses.Th17 cells: a new paradigm for cutaneous inflammation.Serum levels of selected Th17 and Th22 cytokines in psoriatic patients.IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction The role of angiogenesis in the pathogenesis of psoriasis.Where do we stand with the genetics of psoriatic arthritis?

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P2860

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model.

http://www.wikidata.org/entity/Q40156550

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Resolution of psoriasis upon b ...... ty in a xenograft mouse model.

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Resolution of psoriasis upon b ...... ty in a xenograft mouse model.

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Resolution of psoriasis upon b ...... ty in a xenograft mouse model.

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Arnout F Gerritsen

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Frank Beurskens

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Frederik Dagnaes-Hansen

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Jan G J van de Winkel

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Janine Schuurman

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Jorgen Rygaard

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Louise S Villadsen

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Marc A van Dijk

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Marleen M Voorhorst-Ogink

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Ole Baadsgaard

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P2860

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

Continuous cultures of fused cells secreting antibody of predefined specificity

The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens

Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial

IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

Animal models of psoriasis - what can we learn from them?

Interleukin-15 activates proinflammatory and antimicrobial functions in polymorphonuclear cells

The IL-15R alpha chain signals through association with Syk in human B cells.

Interleukin 15: biology and relevance to human disease.

Characterization of lymphocyte-dependent angiogenesis using a SCID mouse: human skin model of psoriasis.

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