Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major.
about
The mating competence of geographically diverse Leishmania major strains in their natural and unnatural sand fly vectorsDemonstration of genetic exchange during cyclical development of Leishmania in the sand fly vectorRetention and loss of RNA interference pathways in trypanosomatid protozoansGolgi-located NTPDase1 of Leishmania major is required for lipophosphoglycan elongation and normal lesion development whereas secreted NTPDase2 is dispensable for virulenceDegradation of host sphingomyelin is essential for Leishmania virulence.Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors.Leishmania UDP-sugar pyrophosphorylase: the missing link in galactose salvage?Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern.Genetic metabolic complementation establishes a requirement for GDP-fucose in Leishmania.Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies.Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania majorThe role of nucleotide sugar transporters in development of eukaryotes.Leukocytes infiltrate the skin and draining lymph nodes in response to the protozoan Leishmania infantum chagasi.Deficiency of Leishmania phosphoglycans influences the magnitude but does not affect the quality of secondary (memory) anti-Leishmania immunityLeishmania lipophosphoglycan: how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?Evaluation of α,β-unsaturated ketones as antileishmanial agents.Identification of a Golgi-localized UDP-N-acetylglucosamine transporter in Trypanosoma cruzi.Comparisons of mutants lacking the Golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicanaRegulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins.The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegansLeishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functionsLeishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hostsA single UDP-galactofuranose transporter is required for galactofuranosylation in Aspergillus fumigatus.The pathogenic fungus Cryptococcus neoformans expresses two functional GDP-mannose transporters with distinct expression patterns and roles in capsule synthesis.In vivo imaging of transgenic Leishmania parasites in a live host.Use of Giardia, which appears to have a single nucleotide-sugar transporter for UDP-GlcNAc, to identify the UDP-Glc transporter of Entamoeba.
P2860
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P1343
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P2860
Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major.
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
@zh-my
2007年学术文章
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2007年學術文章
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name
Two functionally divergent UDP ...... synthesis in Leishmania major.
@en
type
label
Two functionally divergent UDP ...... synthesis in Leishmania major.
@en
prefLabel
Two functionally divergent UDP ...... synthesis in Leishmania major.
@en
P2093
P2860
P921
P356
P1476
Two functionally divergent UDP ...... synthesis in Leishmania major.
@en
P2093
Althea A Capul
Deborah E Dobson
Salvatore J Turco
Tamara Barron
P2860
P304
14006-14017
P356
10.1074/JBC.M610869200
P407
P577
2007-03-08T00:00:00Z