Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells. - Wikidata - awgldk - TriplyDB

Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells.

Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells.

http://www.wikidata.org/entity/Q40165296

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High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function Evidence for Protection against Chronic Hepatitis C Virus Infection in Chimpanzees by Immunization with Replicating Recombinant Vaccinia Virus Sang Froid in a time of trouble: is a vaccine against HIV possible?Candidate vaccine sequences to represent intra- and inter-clade HIV-1 variation.Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.Dynamic regulation of functionally distinct virus-specific T cells.Dynamics of viral evolution and CTL responses in HIV-1 infection T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challenge.Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.Pathogenesis and treatment of HIV infection: the cellular, the immune system and the neuroendocrine systems perspective.Escape is a more common mechanism than avidity reduction for evasion of CD8+ T cell responses in primary human immunodeficiency virus type 1 infection.Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain.High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control High-avidity, high-IFNγ-producing CD8 T-cell responses following immune selection during HIV-1 infection.Epitope targeting and viral inoculum are determinants of Nef-mediated immune evasion of HIV-1 from cytotoxic T lymphocytes Expansion of polyfunctional HIV-specific T cells upon stimulation with mRNA electroporated dendritic cells in the presence of immunomodulatory drugs Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape.Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequences.Magnitude, breadth, and functional profile of T-cell responses during human immunodeficiency virus primary infection with B and BF viral variants.TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells Cross-reactivity of T cells and its role in the immune system Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein.Nonhuman primate models and the failure of the Merck HIV-1 vaccine in humans.Toward an AIDS vaccine.Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vector.CTL quality and the control of human retroviral infections.Immune Signature of Enhanced Functional Avidity CD8+ T Cells in vivo Induced by Vaccinia Vectored Vaccine.T cell sensitivity and the outcome of viral infection.T cells induced by recombinant chimpanzee adenovirus alone and in prime-boost regimens decrease chimeric EcoHIV/NDK challenge virus load Functional avidity: a measure to predict the efficacy of effector T cells?Enhanced cytotoxicity and decreased CD8 dependence of human cancer-specific cytotoxic T lymphocytes after vaccination with low peptide dose.T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone.HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies.Antiviral activity of human immunodeficiency virus type 1 Gag-specific cytotoxic T lymphocyte targeting is not necessarily intrinsically superior to envelope targeting HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes.Retracing our STEP towards a successful CTL-based HIV-1 vaccine.Fine-tuning of T-cell receptor avidity to increase HIV epitope variant recognition by cytotoxic T lymphocytes.Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection

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P2860

Epitope-dependent avidity thresholds for cytotoxic T-lymphocyte clearance of virus-infected cells.

http://www.wikidata.org/entity/Q40165296

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2007 nî lūn-bûn

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Epitope-dependent avidity thre ...... rance of virus-infected cells.

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Ayub Ali

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Hwee L Ng

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Michael S Bennett

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Mirabelle Dagarag

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Otto O Yang

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P2860

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

In vivo cross-presentation of a soluble protein antigen: kinetics, distribution, and generation of effector CTL recognizing dominant and subdominant epitopes.

Study of antigen-processing steps reveals preferences explaining differential biological outcomes of two HLA-A2-restricted immunodominant epitopes from human immunodeficiency virus type 1.

Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen

Will we be able to 'spot' an effective HIV-1 vaccine?

Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms

Cytotoxic T-lymphocyte cross-reactivity among different human immunodeficiency virus type 1 clades: implications for vaccine development.

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10.1128/JVI.02362-06

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17329324

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