Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
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The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesA human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphatePhosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virusPhosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirusInhibition of varicella-zoster virus-induced DNA polymerase by a new guanosine analog, 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine triphosphateActivity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegalovirusesActivity of (+)-cyclaradine (Sch 31172) against herpes simplex virus in vitro and in vivoAntibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U)Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC-96In vitro and in vivo resistance of herpes simplex virus to 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine)Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivoIn vitro susceptibility of varicella-zoster virus to acyclovirAcyclovir inhibition of Epstein-Barr virus replicationAnti-herpes simplex virus and anti-human cell growth activity of E-5-propenyl-2'-deoxyuridine and the concept of selective protection in antivirus chemotherapyEfficacy of acyclovir against mouse cytomegalovirus in vivo9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplicationAnti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profileMode of action of (1'S,2'R)-9-[[1',2'-bis(hydroxymethyl) cycloprop-1'-yl]methyl]guanine (A-5021) against herpes simplex virus type 1 and type 2 and varicella-zoster virus.Analysis of phosphorylation pathways of antiherpesvirus nucleosides by varicella-zoster virus-specific enzymesStructure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of BrivudineA randomised double-blind clinical trial of acyclovir (Zovirax) and adenine arabinoside in herpes simplex corneal ulceration.Targeting of an inducible toxic phenotype in animal cellsSusceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovirRegulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir.Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiencyThymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.Biochemical characterization of equine herpesvirus type 3-induced deoxythymidine kinase purified from lytically infected horse embryo dermal fibroblasts.Comparison of polymorphism of thymidine kinase gene and restriction fragment length polymorphism of genomic DNA in herpes simplex virus type 1.Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein.Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infectionPhase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma.Potent antiviral activity of north-methanocarbathymidine against Kaposi's sarcoma-associated herpesvirus.Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.Proposed mechanisms of action for prostate cancer vaccines.Phosphorylation of acyclovir [9-(2-hydroxyethoxymethyl)guanine] in Epstein-Barr virus-infected lymphoblastoid cell linesEffects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.
P2860
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P2860
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
description
1978 nî lūn-bûn
@nan
1978年の論文
@ja
1978年論文
@yue
1978年論文
@zh-hant
1978年論文
@zh-hk
1978年論文
@zh-mo
1978年論文
@zh-tw
1978年论文
@wuu
1978年论文
@zh
1978年论文
@zh-cn
name
Thymidine kinase from herpes s ...... 2-hydroxyethoxymethyl)guanine.
@en
type
label
Thymidine kinase from herpes s ...... 2-hydroxyethoxymethyl)guanine.
@en
prefLabel
Thymidine kinase from herpes s ...... 2-hydroxyethoxymethyl)guanine.
@en
P2093
P1476
Thymidine kinase from herpes s ...... 2-hydroxyethoxymethyl)guanine.
@en
P2093
P304
P407
P577
1978-12-01T00:00:00Z