Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.
about
GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependenceRole of guanine-nucleotide exchange factor Epac in renal physiology and pathophysiologyCyclic AMP dynamics in the pancreatic β-cellPKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.Cyclic AMP sensor EPAC proteins and energy homeostasis.Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide.Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of LangerhansCoupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysisSimvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells.Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2AMolecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells.cAMP signalling in insulin and glucagon secretion.Facilitation of ß-cell K(ATP) channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac.The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.VMAT2 identified as a regulator of late-stage β-cell differentiation.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
P2860
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P2860
Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Glucose-dependent potentiation ...... ivator 8-pCPT-2'-O-Me-cAMP-AM.
@en
type
label
Glucose-dependent potentiation ...... ivator 8-pCPT-2'-O-Me-cAMP-AM.
@en
prefLabel
Glucose-dependent potentiation ...... ivator 8-pCPT-2'-O-Me-cAMP-AM.
@en
P2093
P2860
P356
P1433
P1476
Glucose-dependent potentiation ...... tivator 8-pCPT-2'-O-Me-cAMP-AM
@en
P2093
Colin A Leech
Elvira Dzhura
Frank Schwede
George G Holz
Grant G Kelley
Igor Dzhura
Michael W Roe
Oleg G Chepurny
Parisa Afshari
Xiangquan Li
P2860
P304
P356
10.4161/ISL.1.3.9645
P577
2009-11-01T00:00:00Z