HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target. - Wikidata - awgldk - TriplyDB

HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.

HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.

http://www.wikidata.org/entity/Q40201466

about

p53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening system MDM2 and MDMX: Alone and together in regulation of p53 N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer.Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4 The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias.Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing.Altered Gene Expression Associated with microRNA Binding Site Polymorphisms Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia Regulation of MDMX expression by mitogenic signaling.MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk.The associations between MDM4 gene polymorphisms and cancer risk Functions of MDMX in the modulation of the p53-response.Chromosome instability and deregulated proliferation: an unavoidable duo.The Mdm network and its regulation of p53 activities: a rheostat of cancer risk.Pharmacological activation of wild-type p53 in the therapy of leukemia.MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis.BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death.p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis.Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases.MDMX is a prognostic factor for non-small cell lung cancer and regulates its sensitivity to cisplatin.The Roles of MDM2 and MDMX in Cancer.In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas.

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P2860

HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target.

http://www.wikidata.org/entity/Q40201466

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

HDM4 (HDMX) is widely expresse ...... potential therapeutic target.

@en

type

label

HDM4 (HDMX) is widely expresse ...... potential therapeutic target.

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prefLabel

HDM4 (HDMX) is widely expresse ...... potential therapeutic target.

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MODPATHOL.3800727

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Modern Pathology

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HDM4 (HDMX) is widely expresse ...... potential therapeutic target.

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P2093

Carlos E Bueso-Ramos

http://www.w3.org/2001/XMLSchema#string

Daniel M Jones

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Gary Rosner

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Georgios Z Rassidakis

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Guillermina Lozano

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Juan Barboza

http://www.w3.org/2001/XMLSchema#string

L Jeffrey Medeiros

http://www.w3.org/2001/XMLSchema#string

Lianchun Xiao

http://www.w3.org/2001/XMLSchema#string

Martin Nguyen

http://www.w3.org/2001/XMLSchema#string

Michael Fernandez

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P2860

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

Mdmx as an essential regulator of p53 activity.

Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity.

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells.

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modpathol.3800727

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54-62

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10.1038/MODPATHOL.3800727

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1

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20

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Hagop Kantarjian

Guillermo Garcia-Manero

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2006-11-24T00:00:00Z

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6656259

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