Toxicity of statins on rat skeletal muscle mitochondria.
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The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicityIs immunity a mechanism contributing to statin-induced diabetes?Statin-Induced Increases in Atrophy Gene Expression Occur Independently of Changes in PGC1α Protein and Mitochondrial ContentStatin-induced Myopathy in Skeletal Muscle: the Role of ExercisePolymorphisms in the mitochondrial ribosome recycling factor EF-G2mt/MEF2 compromise cell respiratory function and increase atorvastatin toxicityDifferential mitochondrial toxicity screening and multi-parametric data analysisDesign considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testingStatin therapy and the expression of genes that regulate calcium homeostasis and membrane repair in skeletal muscle.Selected statins produce rapid spinal motor neuron loss in vitro.Mitophagy is required for acute cardioprotection by simvastatin.Do statins increase and Mediterranean diet decrease the risk of breast cancer?Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3?High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.The acute extracellular flux (XF) assay to assess compound effects on mitochondrial function.Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes.L-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized ratsOpposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1.Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in MiceA model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction.Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity.Strategies to reduce late-stage drug attrition due to mitochondrial toxicity.Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres.Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generationInteraction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues.Simvastatin impairs exercise training adaptations.The role of acid-base imbalance in statin-induced myotoxicityStatin myopathy as a metabolic muscle disease.Molecular basis for statin-induced muscle toxicity: implications and possibilities.Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect.Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity.Pravastatin Chronic Treatment Sensitizes Hypercholesterolemic Mice Muscle to Mitochondrial Permeability Transition: Protection by Creatine or Coenzyme Q10.Isolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization.Statin intolerance: diagnosis and remedies.The role of mitochondria in statin-induced myopathy.Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target?Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo.A systematic assessment of mitochondrial function identified novel signatures for drug-induced mitochondrial disruption in cells.Histopathologic and Biochemical Evidence for Mitochondrial Disease Among 279 Patients with Severe Statin Myopathy.Toxicity of Atorvastatin on Pancreas Mitochondria: A Justification for Increased Risk of Diabetes Mellitus.Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
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Toxicity of statins on rat skeletal muscle mitochondria.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Toxicity of statins on rat skeletal muscle mitochondria.
@en
type
label
Toxicity of statins on rat skeletal muscle mitochondria.
@en
prefLabel
Toxicity of statins on rat skeletal muscle mitochondria.
@en
P2093
P1476
Toxicity of statins on rat skeletal muscle mitochondria.
@en
P2093
P2888
P304
P356
10.1007/S00018-006-6235-Z
P577
2006-10-01T00:00:00Z