The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes.
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The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosomeDefective expression of plectin/HD1 in epidermolysis bullosa simplex with muscular dystrophySignal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomesCalx, a Na-Ca exchanger gene of Drosophila melanogasterThe beta4 integrin interactor p27(BBP/eIF6) is an essential nuclear matrix protein involved in 60S ribosomal subunit assemblyBinding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament bindingHemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunitIsolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cellsIntegrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresiaGenomic organization of the human integrin beta4 geneComparative studies of vertebrate Beta integrin genes and proteins: ancient genes in vertebrate evolutionReversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodiesEffects of sulfur mustard on the basal cell adhesion complex.Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes.Caspase proteolysis of the integrin beta4 subunit disrupts hemidesmosome assembly, promotes apoptosis, and inhibits cell migration.Unique expression pattern of the alpha6beta4 integrin and laminin-5 in human prostate carcinomaAlpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia.Structure and function of a vimentin-associated matrix adhesion in endothelial cellsIntegrin β4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2-mediated secretion of VEGF.Convergence of eicosanoid and integrin biology: 12-lipoxygenase seeks a partner.Compound heterozygosity for missense (L156P) and nonsense (R554X) mutations in the beta4 integrin gene (ITGB4) underlies mild, nonlethal phenotype of epidermolysis bullosa with pyloric atresia.Chromogenic in situ hybridization for alpha6beta4 integrin in breast cancer: correlation with protein expression.Molecular genetic studies of a human epidermal autoantigen (the 180-kD bullous pemphigoid antigen/BP180): identification of functionally important sequences within the BP180 molecule and evidence for an interaction between BP180 and alpha 6 integrinEGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion.Compartmentalization of integrin alpha6beta4 signaling in lipid raftsA recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins.Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes.The roles of integrin β4 in vascular endothelial cells.Variation in contact guidance by human cells on a microstructured surface.SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells.Functional characterization of integrin alpha6beta4 adhesion interactions using soluble integrin constructs reveals the involvement of different functional domains in the beta4 subunit.Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells.The impact of molecular biology on models for cell adhesion.Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses.Linking integrin alpha6beta4-based cell adhesion to the intermediate filament cytoskeleton: direct interaction between the beta4 subunit and plectin at multiple molecular sites.Activation of the p21 pathway of growth arrest and apoptosis by the beta 4 integrin cytoplasmic domain.The integrin alpha 6 beta 4 and the biology of carcinoma.Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.The intracellular functions of alpha6beta4 integrin are regulated by EGF.
P2860
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P2860
The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
The beta 4 subunit cytoplasmic ...... ytoskeleton of hemidesmosomes.
@en
type
label
The beta 4 subunit cytoplasmic ...... ytoskeleton of hemidesmosomes.
@en
prefLabel
The beta 4 subunit cytoplasmic ...... ytoskeleton of hemidesmosomes.
@en
P2093
P2860
P356
P1476
The beta 4 subunit cytoplasmic ...... ytoskeleton of hemidesmosomes.
@en
P2093
F G Giancotti
L Spinardi
P2860
P304
P356
10.1091/MBC.4.9.871
P577
1993-09-01T00:00:00Z