Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro.
about
Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutantsPPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersMammalian P4-ATPases and ABC transporters and their role in phospholipid transportMolecular mechanisms of disease-causing missense mutationsWill Lipidation of ApoA1 through Interaction with ABCA1 at the Intestinal Level Affect the Protective Functions of HDL?Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunctionA functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans.ABCA1 and nascent HDL biogenesisType 2 diabetes is associated with reduced ATP-binding cassette transporter A1 gene expression, protein and functionClinical, Biochemical, and Molecular Characterization of Novel Mutations in ABCA1 in Families with Tangier DiseaseLXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.Targeted next-generation sequencing to diagnose disorders of HDL cholesterol.Anticancer activity of the cholesterol exporter ABCA1 gene.BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ATP-binding cassette transporter A-1 trafficking and function.Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages.Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritisABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor.Lipid outward translocation by ABC proteins.ABC proteins protect the human body and maintain optimal health.Function and regulation of ABCA1--membrane meso-domain organization and reorganization.Genetics of HDL-C: a causal link to atherosclerosis?Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation.Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity.Increased Systemic and Plaque Inflammation in ABCA1 Mutation Carriers With Attenuation by Statins.Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept.A Comprehensive In Silico Analysis of the Functional and Structural Impact of Nonsynonymous SNPs in the ABCA1 Transporter Gene.Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1.Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate.ABCA1 mediates unfolding of apolipoprotein AI N terminus on the cell surface before lipidation and release of nascent high-density lipoprotein.ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden.Is ABCA1 a Lipid Transfer Protein?Clinical utility gene card for: Tangier disease.The effects of neurological disorder-related codon variations of ABCA13 on the function of the ABC protein.
P2860
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P2860
Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Specific mutations in ABCA1 ha ...... pes both in vivo and in vitro.
@en
type
label
Specific mutations in ABCA1 ha ...... pes both in vivo and in vitro.
@en
prefLabel
Specific mutations in ABCA1 ha ...... pes both in vivo and in vitro.
@en
P2093
P1433
P1476
Specific mutations in ABCA1 ha ...... pes both in vivo and in vitro.
@en
P2093
Angeliki Chroni
Erick R James
Giovanna Chimini
Henk Visscher
Jonathan M Coutinho
Liam R Brunham
Martin H Kang
Roshni R Singaraja
P304
P356
10.1161/01.RES.0000237920.70451.AD
P577
2006-07-27T00:00:00Z