Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.
about
Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responsesComparative analysis of species-specific ligand recognition in Toll-like receptor 8 signaling: a hypothesisGuanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cellsToll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNARNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8.Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.TLR-based immune adjuvants.A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligandNo longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammationToll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity.TLR7 and TLR8 as targets in cancer therapy.DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivoClassification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.Modulating toll-like receptor 7 and 9 responses as therapy for allergy and autoimmunity.Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3.Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD14 (in TLR-mediated effects).TLR2 and TLR4 gene expression levels and associated factors during acute attack and attack-free periods in familial Mediterranean fever.Bioconjugation of Small Molecules to RNA Impedes Its Recognition by Toll-Like Receptor 7.Synergistic activation of Toll-like receptor 8 by two RNA degradation products.Downregulation of TLR-7 receptor in hepatic and non-hepatic patients with lichen planus.Engagement of the B cell receptor for antigen differentially affects B cell responses to Toll-like receptor-7 agonists and antagonists in BXSB mice.
P2860
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P2860
Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Modulating responsiveness of h ...... othiate oligodeoxynucleotides.
@en
type
label
Modulating responsiveness of h ...... othiate oligodeoxynucleotides.
@en
prefLabel
Modulating responsiveness of h ...... othiate oligodeoxynucleotides.
@en
P2093
P2860
P356
P1476
Modulating responsiveness of h ...... othiate oligodeoxynucleotides.
@en
P2093
Andrea Kritzler
Arthur M Krieg
Bettina Schulte
Christian Schetter
Jörg Vollmer
Marion Jurk
Sibylle Tluk
P2860
P304
P356
10.1002/EJI.200535806
P407
P577
2006-07-01T00:00:00Z