The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling.
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Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesStructural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorCryo-EM structure of the activated GLP-1 receptor in complex with a G protein.Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.Crystal structure of the GLP-1 receptor bound to a peptide agonist.
P2860
Q28067465-01E11929-CF10-4403-BD1C-290BEB5E67E0Q28274664-1A3C341F-04B1-4033-A0DF-3CF4CD1498CEQ28278129-500C9EFD-11E7-4480-BAB1-85A575F66F29Q41597824-E05C2D53-0101-4A40-923F-E52D57327618Q41598194-0EAC6B6C-ABBC-4E26-A8F2-E694640D05EDQ41830097-3190A024-0160-4B0F-BFBF-EA71049C7B21Q50968563-F79681FD-543C-4287-AC6A-E737B4CB4CA4
P2860
The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling.
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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name
The peptide agonist-binding si ...... and knowledge-based modelling.
@en
type
label
The peptide agonist-binding si ...... and knowledge-based modelling.
@en
prefLabel
The peptide agonist-binding si ...... and knowledge-based modelling.
@en
P2860
P356
P1154
2-s2.0-84956940118
P1433
P1476
The peptide agonist-binding si ...... and knowledge-based modelling.
@en
P2093
Dan Donnelly
Rachel L Dods
P2860
P304
P356
10.1042/BSR20150253
P577
2015-11-23T00:00:00Z